An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity

We recently characterized Winnie mice carrying a missense mutation in Muc2, leading to severe endoplasmic reticulum stress in intestinal goblet cells and spontaneous colitis. In this study, we characterized the immune responses due to this intestinal epithelial dysfunction. In Winnie, there was a fo...

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Detalles Bibliográficos
Autores principales: Eri, R D, Adams, R J, Tran, T V, Tong, H, Das, I, Roche, D K, Oancea, I, Png, C W, Jeffery, P L, Radford-Smith, G L, Cook, M C, Florin, T H, McGuckin, M A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130192/
https://www.ncbi.nlm.nih.gov/pubmed/21107311
http://dx.doi.org/10.1038/mi.2010.74

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