GPHMM: an integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arrays

There is an increasing interest in using single nucleotide polymorphism (SNP) genotyping arrays for profiling chromosomal rearrangements in tumors, as they allow simultaneous detection of copy number and loss of heterozygosity with high resolution. Critical issues such as signal baseline shift due t...

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Detalles Bibliográficos
Autores principales: Li, Ao, Liu, Zongzhi, Lezon-Geyda, Kimberly, Sarkar, Sudipa, Lannin, Donald, Schulz, Vincent, Krop, Ian, Winer, Eric, Harris, Lyndsay, Tuck, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130254/
https://www.ncbi.nlm.nih.gov/pubmed/21398628
http://dx.doi.org/10.1093/nar/gkr014

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