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G4 motifs correlate with promoter-proximal transcriptional pausing in human genes

The RNA Pol II transcription complex pauses just downstream of the promoter in a significant fraction of human genes. The local features of genomic structure that contribute to pausing have not been defined. Here, we show that genes that pause are more G-rich within the region flanking the transcrip...

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Detalles Bibliográficos
Autores principales:	Eddy, Johanna, Vallur, Aarthy C., Varma, Sudir, Liu, Hongfang, Reinhold, William C., Pommier, Yves, Maizels, Nancy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130262/ https://www.ncbi.nlm.nih.gov/pubmed/21371997 http://dx.doi.org/10.1093/nar/gkr079

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