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Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods

The establishment of multiplex photoacoustic molecular imaging to characterize heterogeneous tissues requires the use of a tunable, thermally stable contrast agent targeted to specific cell types. We have developed a multiplex photoacoustic imaging technique which uses targeted silica-coated gold na...

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Autores principales: Bayer, Carolyn L., Chen, Yun-Sheng, Kim, Seungsoo, Mallidi, Srivalleesha, Sokolov, Konstantin, Emelianov, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130570/
https://www.ncbi.nlm.nih.gov/pubmed/21750761
http://dx.doi.org/10.1364/BOE.2.001828
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author Bayer, Carolyn L.
Chen, Yun-Sheng
Kim, Seungsoo
Mallidi, Srivalleesha
Sokolov, Konstantin
Emelianov, Stanislav
author_facet Bayer, Carolyn L.
Chen, Yun-Sheng
Kim, Seungsoo
Mallidi, Srivalleesha
Sokolov, Konstantin
Emelianov, Stanislav
author_sort Bayer, Carolyn L.
collection PubMed
description The establishment of multiplex photoacoustic molecular imaging to characterize heterogeneous tissues requires the use of a tunable, thermally stable contrast agent targeted to specific cell types. We have developed a multiplex photoacoustic imaging technique which uses targeted silica-coated gold nanorods to distinguish cell inclusions in vitro. This paper describes the use of tunable targeted silica-coated gold nanorods (SiO(2)-AuNRs) as contrast agents for photoacoustic molecular imaging. SiO(2)-AuNRs with peak absorption wavelengths of 780 nm and 830 nm were targeted to cells expressing different cell receptors. Cells were incubated with the targeted SiO(2)-AuNRs, incorporated in a tissue phantom, and imaged using multiwavelength photoacoustic imaging. We used photoacoustic imaging and statistical correlation analysis to distinguish between the unique cell inclusions within the tissue phantom.
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spelling pubmed-31305702011-07-12 Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods Bayer, Carolyn L. Chen, Yun-Sheng Kim, Seungsoo Mallidi, Srivalleesha Sokolov, Konstantin Emelianov, Stanislav Biomed Opt Express Photoacoustic Imaging and Spectroscopy The establishment of multiplex photoacoustic molecular imaging to characterize heterogeneous tissues requires the use of a tunable, thermally stable contrast agent targeted to specific cell types. We have developed a multiplex photoacoustic imaging technique which uses targeted silica-coated gold nanorods to distinguish cell inclusions in vitro. This paper describes the use of tunable targeted silica-coated gold nanorods (SiO(2)-AuNRs) as contrast agents for photoacoustic molecular imaging. SiO(2)-AuNRs with peak absorption wavelengths of 780 nm and 830 nm were targeted to cells expressing different cell receptors. Cells were incubated with the targeted SiO(2)-AuNRs, incorporated in a tissue phantom, and imaged using multiwavelength photoacoustic imaging. We used photoacoustic imaging and statistical correlation analysis to distinguish between the unique cell inclusions within the tissue phantom. Optical Society of America 2011-06-02 /pmc/articles/PMC3130570/ /pubmed/21750761 http://dx.doi.org/10.1364/BOE.2.001828 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Photoacoustic Imaging and Spectroscopy
Bayer, Carolyn L.
Chen, Yun-Sheng
Kim, Seungsoo
Mallidi, Srivalleesha
Sokolov, Konstantin
Emelianov, Stanislav
Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title_full Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title_fullStr Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title_full_unstemmed Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title_short Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
title_sort multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods
topic Photoacoustic Imaging and Spectroscopy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130570/
https://www.ncbi.nlm.nih.gov/pubmed/21750761
http://dx.doi.org/10.1364/BOE.2.001828
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