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Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130582/ https://www.ncbi.nlm.nih.gov/pubmed/21750773 http://dx.doi.org/10.1364/BOE.2.001969 |
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author | Irwin, Daniel Dong, Lixin Shang, Yu Cheng, Ran Kudrimoti, Mahesh Stevens, Scott D. Yu, Guoqiang |
author_facet | Irwin, Daniel Dong, Lixin Shang, Yu Cheng, Ran Kudrimoti, Mahesh Stevens, Scott D. Yu, Guoqiang |
author_sort | Irwin, Daniel |
collection | PubMed |
description | In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms and measured concurrently with the flow index using a hybrid optical system combining a dual-wavelength DCS flow device with a commercial frequency-domain tissue-oximeter. DCS flow indices are calculated at two wavelengths (785 and 830 nm) using measured µ(a) and µ(s)′ or assumed constant µ(a) and µ(s)′. Inaccurate µ(s)′ assumptions resulted in much greater flow index errors than inaccurate µ(a). Underestimated/overestimated µ(s)′ from −35%/+175% lead to flow index errors of +110%/−80%, whereas underestimated/overestimated µ(a) from −40%/+150% lead to −20%/+40%, regardless of the wavelengths used. Examination of a clinical study involving human head and neck tumors indicates up to +280% flow index errors resulted from inter-patient optical property variations. These findings suggest that studies involving significant µ(a) and µ(s)′ changes should concurrently measure flow index and optical properties for accurate extraction of blood flow information. |
format | Online Article Text |
id | pubmed-3130582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-31305822011-07-12 Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements Irwin, Daniel Dong, Lixin Shang, Yu Cheng, Ran Kudrimoti, Mahesh Stevens, Scott D. Yu, Guoqiang Biomed Opt Express Noninvasive Optical Diagnostics In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms and measured concurrently with the flow index using a hybrid optical system combining a dual-wavelength DCS flow device with a commercial frequency-domain tissue-oximeter. DCS flow indices are calculated at two wavelengths (785 and 830 nm) using measured µ(a) and µ(s)′ or assumed constant µ(a) and µ(s)′. Inaccurate µ(s)′ assumptions resulted in much greater flow index errors than inaccurate µ(a). Underestimated/overestimated µ(s)′ from −35%/+175% lead to flow index errors of +110%/−80%, whereas underestimated/overestimated µ(a) from −40%/+150% lead to −20%/+40%, regardless of the wavelengths used. Examination of a clinical study involving human head and neck tumors indicates up to +280% flow index errors resulted from inter-patient optical property variations. These findings suggest that studies involving significant µ(a) and µ(s)′ changes should concurrently measure flow index and optical properties for accurate extraction of blood flow information. Optical Society of America 2011-06-17 /pmc/articles/PMC3130582/ /pubmed/21750773 http://dx.doi.org/10.1364/BOE.2.001969 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Noninvasive Optical Diagnostics Irwin, Daniel Dong, Lixin Shang, Yu Cheng, Ran Kudrimoti, Mahesh Stevens, Scott D. Yu, Guoqiang Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title | Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title_full | Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title_fullStr | Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title_full_unstemmed | Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title_short | Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
title_sort | influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements |
topic | Noninvasive Optical Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130582/ https://www.ncbi.nlm.nih.gov/pubmed/21750773 http://dx.doi.org/10.1364/BOE.2.001969 |
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