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Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements

In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms a...

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Autores principales: Irwin, Daniel, Dong, Lixin, Shang, Yu, Cheng, Ran, Kudrimoti, Mahesh, Stevens, Scott D., Yu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130582/
https://www.ncbi.nlm.nih.gov/pubmed/21750773
http://dx.doi.org/10.1364/BOE.2.001969
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author Irwin, Daniel
Dong, Lixin
Shang, Yu
Cheng, Ran
Kudrimoti, Mahesh
Stevens, Scott D.
Yu, Guoqiang
author_facet Irwin, Daniel
Dong, Lixin
Shang, Yu
Cheng, Ran
Kudrimoti, Mahesh
Stevens, Scott D.
Yu, Guoqiang
author_sort Irwin, Daniel
collection PubMed
description In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms and measured concurrently with the flow index using a hybrid optical system combining a dual-wavelength DCS flow device with a commercial frequency-domain tissue-oximeter. DCS flow indices are calculated at two wavelengths (785 and 830 nm) using measured µ(a) and µ(s)′ or assumed constant µ(a) and µ(s)′. Inaccurate µ(s)′ assumptions resulted in much greater flow index errors than inaccurate µ(a). Underestimated/overestimated µ(s)′ from −35%/+175% lead to flow index errors of +110%/−80%, whereas underestimated/overestimated µ(a) from −40%/+150% lead to −20%/+40%, regardless of the wavelengths used. Examination of a clinical study involving human head and neck tumors indicates up to +280% flow index errors resulted from inter-patient optical property variations. These findings suggest that studies involving significant µ(a) and µ(s)′ changes should concurrently measure flow index and optical properties for accurate extraction of blood flow information.
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spelling pubmed-31305822011-07-12 Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements Irwin, Daniel Dong, Lixin Shang, Yu Cheng, Ran Kudrimoti, Mahesh Stevens, Scott D. Yu, Guoqiang Biomed Opt Express Noninvasive Optical Diagnostics In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µ(a)) and reduced scattering coefficient (µ(s)′), are independently varied using liquid phantoms and measured concurrently with the flow index using a hybrid optical system combining a dual-wavelength DCS flow device with a commercial frequency-domain tissue-oximeter. DCS flow indices are calculated at two wavelengths (785 and 830 nm) using measured µ(a) and µ(s)′ or assumed constant µ(a) and µ(s)′. Inaccurate µ(s)′ assumptions resulted in much greater flow index errors than inaccurate µ(a). Underestimated/overestimated µ(s)′ from −35%/+175% lead to flow index errors of +110%/−80%, whereas underestimated/overestimated µ(a) from −40%/+150% lead to −20%/+40%, regardless of the wavelengths used. Examination of a clinical study involving human head and neck tumors indicates up to +280% flow index errors resulted from inter-patient optical property variations. These findings suggest that studies involving significant µ(a) and µ(s)′ changes should concurrently measure flow index and optical properties for accurate extraction of blood flow information. Optical Society of America 2011-06-17 /pmc/articles/PMC3130582/ /pubmed/21750773 http://dx.doi.org/10.1364/BOE.2.001969 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Noninvasive Optical Diagnostics
Irwin, Daniel
Dong, Lixin
Shang, Yu
Cheng, Ran
Kudrimoti, Mahesh
Stevens, Scott D.
Yu, Guoqiang
Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title_full Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title_fullStr Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title_full_unstemmed Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title_short Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
title_sort influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements
topic Noninvasive Optical Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130582/
https://www.ncbi.nlm.nih.gov/pubmed/21750773
http://dx.doi.org/10.1364/BOE.2.001969
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