Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway

PURPOSE: Transforming growth factor-β2 (TGF-β2) is associated with glaucomatous neuropathy, primarily via the increased synthesis and secretion of extracellular matrix (ECM) proteins and remodeling of the optic nerve head (ONH). Here, we investigated the signaling pathways used by TGF-β2 to stimulat...

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Detalles Bibliográficos
Autores principales: Zode, Gulab S., Sethi, Anirudh, Brun-Zinkernagel, Anne-Marie, Chang, I-Fen, Clark, Abbot F., Wordinger, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130727/
https://www.ncbi.nlm.nih.gov/pubmed/21738403

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