Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

PURPOSE: Rho-kinase regulates activation of hepatic stellate cells (HSC) during liver fibrosis, but the ubiquitous presence of this kinase may hinder examination of its exact role and the therapeutic use of inhibitors. We therefore coupled the Rho-kinase inhibitor Y27632 to a drug carrier that binds...

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Detalles Bibliográficos
Autores principales: van Beuge, Marike Marjolijn, Prakash, Jai, Lacombe, Marie, Post, Eduard, Reker-Smit, Catharina, Beljaars, Leonie, Poelstra, Klaas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130909/
https://www.ncbi.nlm.nih.gov/pubmed/21442374
http://dx.doi.org/10.1007/s11095-011-0430-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130909/
https://www.ncbi.nlm.nih.gov/pubmed/21442374
http://dx.doi.org/10.1007/s11095-011-0430-9

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