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Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma

BACKGROUND: The purpose of this study was to assess the effect of bevacizumab in maintaining intraocular pressure lowered by trabeculectomy in refractory open-angle glaucoma. METHODS: Thirty-seven eyes from 37 patients referring to Nikoukari Ophthalmology University Hospital in Tabriz were enrolled...

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Autores principales: Sedghipour, Mohammad-Reza, Mostafaei, Ali, Taghavi, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130917/
https://www.ncbi.nlm.nih.gov/pubmed/21750613
http://dx.doi.org/10.2147/OPTH.S17896
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author Sedghipour, Mohammad-Reza
Mostafaei, Ali
Taghavi, Yousef
author_facet Sedghipour, Mohammad-Reza
Mostafaei, Ali
Taghavi, Yousef
author_sort Sedghipour, Mohammad-Reza
collection PubMed
description BACKGROUND: The purpose of this study was to assess the effect of bevacizumab in maintaining intraocular pressure lowered by trabeculectomy in refractory open-angle glaucoma. METHODS: Thirty-seven eyes from 37 patients referring to Nikoukari Ophthalmology University Hospital in Tabriz were enrolled in this randomized clinical trial. Seventeen patients were randomly assigned to receive bevacizumab augmentation after trabeculectomy, and 20 patients were assigned to a control group receiving a placebo injection of normal saline. Bevacizumab was injected subconjunctivally at a dose of 0.2 mg. Intraocular pressure was measured on eight occasions, ie, at baseline, 24 hours, 3 days, 7 days, 2 weeks, 1 month, 2 months, and 3 months after treatment. RESULTS: Men constituted 81% of the participants, who were of mean age 67.5 years. Twenty-nine patients had secondary open-angle glaucoma, while eight patients had primary open-angle glaucoma. Intraocular pressure decreased from a mean of 28.4 mmHg at baseline to a mean of 12.1 mmHg during the first day and to 15.1 mmHg after 3 months. Adding bevacizumab to trabeculectomy was not found to affect intraocular pressure differently to placebo. Neither the results of repeated measurements analysis nor single comparison statistical tests were significant for a difference in efficacy of bevacizumab versus placebo. CONCLUSION: Subconjunctival bevacizumab 0.2 mg was not found to affect the trend in intraocular pressure more than placebo after trabeculectomy for open-angle glaucoma.
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spelling pubmed-31309172011-07-12 Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma Sedghipour, Mohammad-Reza Mostafaei, Ali Taghavi, Yousef Clin Ophthalmol Original Research BACKGROUND: The purpose of this study was to assess the effect of bevacizumab in maintaining intraocular pressure lowered by trabeculectomy in refractory open-angle glaucoma. METHODS: Thirty-seven eyes from 37 patients referring to Nikoukari Ophthalmology University Hospital in Tabriz were enrolled in this randomized clinical trial. Seventeen patients were randomly assigned to receive bevacizumab augmentation after trabeculectomy, and 20 patients were assigned to a control group receiving a placebo injection of normal saline. Bevacizumab was injected subconjunctivally at a dose of 0.2 mg. Intraocular pressure was measured on eight occasions, ie, at baseline, 24 hours, 3 days, 7 days, 2 weeks, 1 month, 2 months, and 3 months after treatment. RESULTS: Men constituted 81% of the participants, who were of mean age 67.5 years. Twenty-nine patients had secondary open-angle glaucoma, while eight patients had primary open-angle glaucoma. Intraocular pressure decreased from a mean of 28.4 mmHg at baseline to a mean of 12.1 mmHg during the first day and to 15.1 mmHg after 3 months. Adding bevacizumab to trabeculectomy was not found to affect intraocular pressure differently to placebo. Neither the results of repeated measurements analysis nor single comparison statistical tests were significant for a difference in efficacy of bevacizumab versus placebo. CONCLUSION: Subconjunctival bevacizumab 0.2 mg was not found to affect the trend in intraocular pressure more than placebo after trabeculectomy for open-angle glaucoma. Dove Medical Press 2011 2011-06-15 /pmc/articles/PMC3130917/ /pubmed/21750613 http://dx.doi.org/10.2147/OPTH.S17896 Text en © 2011 Sedghipour et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Sedghipour, Mohammad-Reza
Mostafaei, Ali
Taghavi, Yousef
Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title_full Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title_fullStr Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title_full_unstemmed Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title_short Low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
title_sort low-dose subconjunctival bevacizumab to augment trabeculectomy for glaucoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130917/
https://www.ncbi.nlm.nih.gov/pubmed/21750613
http://dx.doi.org/10.2147/OPTH.S17896
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