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Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
Poorly water-soluble drugs, such as phenylephrine, offer challenging problems for buccal drug delivery. In order to overcome these problems, particle size reduction (to the nanometer range) and cyclodextrin complexation were investigated for permeability enhancement. The apparent solubility in water...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131191/ https://www.ncbi.nlm.nih.gov/pubmed/21753876 http://dx.doi.org/10.2147/IJN.S19151 |