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Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL), whereas the highly related HTLV-2 is not associated with ATL or other cancers. In addition to ATL leukemogenesis, studies of the HTLV viruses also provide an exceptional model for unders...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131208/ https://www.ncbi.nlm.nih.gov/pubmed/21743832 http://dx.doi.org/10.3390/v3060714 |
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author | Qu, Zhaoxia Xiao, Gutian |
author_facet | Qu, Zhaoxia Xiao, Gutian |
author_sort | Qu, Zhaoxia |
collection | PubMed |
description | Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL), whereas the highly related HTLV-2 is not associated with ATL or other cancers. In addition to ATL leukemogenesis, studies of the HTLV viruses also provide an exceptional model for understanding basic pathogenic mechanisms of virus-host interactions and human oncogenesis. Accumulating evidence suggests that the viral regulatory protein Tax and host inflammatory transcription factor NF-κB are largely responsible for the different pathogenic potentials of HTLV-1 and HTLV-2. Here, we discuss the molecular mechanisms of HTLV-1 oncogenic pathogenesis with a focus on the interplay between the Tax oncoprotein and NF-κB pro-oncogenic signaling. We also outline some of the most intriguing and outstanding questions in the fields of HTLV and NF-κB. Answers to those questions will greatly advance our understanding of ATL leukemogenesis and other NF-κB-associated tumorigenesis and will help us design personalized cancer therapies. |
format | Online Article Text |
id | pubmed-3131208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31312082011-07-07 Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis Qu, Zhaoxia Xiao, Gutian Viruses Review Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATL), whereas the highly related HTLV-2 is not associated with ATL or other cancers. In addition to ATL leukemogenesis, studies of the HTLV viruses also provide an exceptional model for understanding basic pathogenic mechanisms of virus-host interactions and human oncogenesis. Accumulating evidence suggests that the viral regulatory protein Tax and host inflammatory transcription factor NF-κB are largely responsible for the different pathogenic potentials of HTLV-1 and HTLV-2. Here, we discuss the molecular mechanisms of HTLV-1 oncogenic pathogenesis with a focus on the interplay between the Tax oncoprotein and NF-κB pro-oncogenic signaling. We also outline some of the most intriguing and outstanding questions in the fields of HTLV and NF-κB. Answers to those questions will greatly advance our understanding of ATL leukemogenesis and other NF-κB-associated tumorigenesis and will help us design personalized cancer therapies. Molecular Diversity Preservation International (MDPI) 2011-06-10 /pmc/articles/PMC3131208/ /pubmed/21743832 http://dx.doi.org/10.3390/v3060714 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Qu, Zhaoxia Xiao, Gutian Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title | Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title_full | Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title_fullStr | Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title_full_unstemmed | Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title_short | Human T-Cell Lymphotropic Virus: A Model of NF-κB-Associated Tumorigenesis |
title_sort | human t-cell lymphotropic virus: a model of nf-κb-associated tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131208/ https://www.ncbi.nlm.nih.gov/pubmed/21743832 http://dx.doi.org/10.3390/v3060714 |
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