Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages

BACKGROUND: Although HIV can infect several cellular subsets, such as CD4(+ )T lymphocytes and macrophages, it remains unclear whether an HIV infection in macrophages supports cytotoxic T lymphocyte (CTL) escape. Here, we tested two naturally-arising mutations located in the well-conserved polyproli...

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Detalles Bibliográficos
Autores principales: Mwimanzi, Philip, Hasan, Zafrul, Hassan, Ranya, Suzu, Shinya, Takiguchi, Masafumi, Ueno, Takamasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131245/
https://www.ncbi.nlm.nih.gov/pubmed/21696586
http://dx.doi.org/10.1186/1742-4690-8-50

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