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The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance
BACKGROUND: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carci...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131255/ https://www.ncbi.nlm.nih.gov/pubmed/21696600 http://dx.doi.org/10.1186/1479-5876-9-95 |
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author | Xie, Fei Ye, Lin Chen, Jinfeng Wu, Nan Zhang, Zhiqian Yang, Yue Zhang, Lijian Jiang, Wen G |
author_facet | Xie, Fei Ye, Lin Chen, Jinfeng Wu, Nan Zhang, Zhiqian Yang, Yue Zhang, Lijian Jiang, Wen G |
author_sort | Xie, Fei |
collection | PubMed |
description | BACKGROUND: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported. METHODS: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells. RESULTS: Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness. CONCLUSION: MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy. |
format | Online Article Text |
id | pubmed-3131255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31312552011-07-08 The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance Xie, Fei Ye, Lin Chen, Jinfeng Wu, Nan Zhang, Zhiqian Yang, Yue Zhang, Lijian Jiang, Wen G J Transl Med Research BACKGROUND: Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal squamous cell carcinoma (ESCC) has not been reported. METHODS: In this study, we assessed the expression levels of MTSS1 in tumours and its matched adjacent non-tumour tissues obtained from 105 ESCC patients. We also used ESCC cells with differing MTSS1 expression and assessed the influence of MTSS1 on ESCC cells. RESULTS: Down-regulation of MTSS1 expression was observed both in oesophageal tumour tissues and ESCC cancer cell lines. We also reported that MTSS1 expression was associated with tumour grade (p = 0.024), lymph node metastasis (p = 0.010) and overall survival (p = 0.035). Patients with high levels of MTSS1 transcripts had a favorable prognosis in comparison with those who had reduced or absent expression levels. Using over-expression and knockdown approach, we created sublines from ESCC cells and further demonstrated that MTSS1 expression in ESCC cells significantly influenced the aggressiveness of the oesophageal cancer cells, by reducing their cellular migration and in vitro invasiveness. CONCLUSION: MTSS1 serves as a potential prognostic indicator in human ESCC and may be an important target for cancer therapy. BioMed Central 2011-06-22 /pmc/articles/PMC3131255/ /pubmed/21696600 http://dx.doi.org/10.1186/1479-5876-9-95 Text en Copyright ©2011 Xie et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Xie, Fei Ye, Lin Chen, Jinfeng Wu, Nan Zhang, Zhiqian Yang, Yue Zhang, Lijian Jiang, Wen G The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title | The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title_full | The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title_fullStr | The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title_full_unstemmed | The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title_short | The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance |
title_sort | impact of metastasis suppressor-1, mtss1, on oesophageal squamous cell carcinoma and its clinical significance |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131255/ https://www.ncbi.nlm.nih.gov/pubmed/21696600 http://dx.doi.org/10.1186/1479-5876-9-95 |
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