Microenvironmental Influence on Pre-Clinical Activity of Polo-Like Kinase Inhibition in Multiple Myeloma: Implications for Clinical Translation

Polo-like kinases (PLKs) play an important role in cell cycle progression, checkpoint control and mitosis. The high mitotic index and chromosomal instability of advanced cancers suggest that PLK inhibitors may be an attractive therapeutic option for presently incurable advanced neoplasias with syste...

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Detalles Bibliográficos
Autores principales: McMillin, Douglas W., Delmore, Jake, Negri, Joseph, Ooi, Melissa, Klippel, Steffen, Miduturu, Chandrasekhar V., Gray, Nathanael S., Richardson, Paul G., Anderson, Kenneth C., Kung, Andrew L., Mitsiades, Constantine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131271/
https://www.ncbi.nlm.nih.gov/pubmed/21750699
http://dx.doi.org/10.1371/journal.pone.0020226

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