Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design

Therapeutic RNA interference has emerged as a promising approach for the treatment of many incurable diseases, including cancer, infectious disease or neurodegenerative disorders. Demonstration of efficacy and safety in animal models is necessary before planning human application. Our group and othe...

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Detalles Bibliográficos
Autores principales: Martin, Janine N, Wolken, Nicolle, Brown, Timothy, Dauer, William T, Ehrlich, Michelle E, Gonzalez-Alegre, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131434/
https://www.ncbi.nlm.nih.gov/pubmed/21368900
http://dx.doi.org/10.1038/gt.2011.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131434/
https://www.ncbi.nlm.nih.gov/pubmed/21368900
http://dx.doi.org/10.1038/gt.2011.10

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