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Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
Therapeutic RNA interference has emerged as a promising approach for the treatment of many incurable diseases, including cancer, infectious disease or neurodegenerative disorders. Demonstration of efficacy and safety in animal models is necessary before planning human application. Our group and othe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131434/ https://www.ncbi.nlm.nih.gov/pubmed/21368900 http://dx.doi.org/10.1038/gt.2011.10 |