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Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives
Gastrointestinal motility research is progressing rapidly, leading to significant advances in the last 15 years in understanding the cellular mechanisms underlying motility, following the discovery of the central role played by the interstitial cells of Cajal (ICC). As experimental knowledge of ICC...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131535/ https://www.ncbi.nlm.nih.gov/pubmed/21772822 http://dx.doi.org/10.3389/fphys.2011.00029 |
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author | Lees-Green, Rachel Du, Peng O’Grady, Gregory Beyder, Arthur Farrugia, Gianrico Pullan, Andrew J. |
author_facet | Lees-Green, Rachel Du, Peng O’Grady, Gregory Beyder, Arthur Farrugia, Gianrico Pullan, Andrew J. |
author_sort | Lees-Green, Rachel |
collection | PubMed |
description | Gastrointestinal motility research is progressing rapidly, leading to significant advances in the last 15 years in understanding the cellular mechanisms underlying motility, following the discovery of the central role played by the interstitial cells of Cajal (ICC). As experimental knowledge of ICC physiology has expanded, biophysically based modeling has become a valuable tool for integrating experimental data, for testing hypotheses on ICC pacemaker mechanisms, and for applications in in silico studies including in multiscale models. This review is focused on the cellular electrophysiology of ICC. Recent evidence from both experimental and modeling domains have called aspects of the existing pacemaker theories into question. Therefore, current experimental knowledge of ICC pacemaker mechanisms is examined in depth, and current theories of ICC pacemaking are evaluated and further developed. Existing biophysically based ICC models and their physiological foundations are then critiqued in light of the recent advances in experimental knowledge, and opportunities to improve these models are identified. The review concludes by examining several potential clinical applications of biophysically based ICC modeling from the subcellular through to the organ level, including ion channelopathies and ICC network degradation. |
format | Online Article Text |
id | pubmed-3131535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31315352011-07-19 Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives Lees-Green, Rachel Du, Peng O’Grady, Gregory Beyder, Arthur Farrugia, Gianrico Pullan, Andrew J. Front Physiol Physiology Gastrointestinal motility research is progressing rapidly, leading to significant advances in the last 15 years in understanding the cellular mechanisms underlying motility, following the discovery of the central role played by the interstitial cells of Cajal (ICC). As experimental knowledge of ICC physiology has expanded, biophysically based modeling has become a valuable tool for integrating experimental data, for testing hypotheses on ICC pacemaker mechanisms, and for applications in in silico studies including in multiscale models. This review is focused on the cellular electrophysiology of ICC. Recent evidence from both experimental and modeling domains have called aspects of the existing pacemaker theories into question. Therefore, current experimental knowledge of ICC pacemaker mechanisms is examined in depth, and current theories of ICC pacemaking are evaluated and further developed. Existing biophysically based ICC models and their physiological foundations are then critiqued in light of the recent advances in experimental knowledge, and opportunities to improve these models are identified. The review concludes by examining several potential clinical applications of biophysically based ICC modeling from the subcellular through to the organ level, including ion channelopathies and ICC network degradation. Frontiers Research Foundation 2011-07-04 /pmc/articles/PMC3131535/ /pubmed/21772822 http://dx.doi.org/10.3389/fphys.2011.00029 Text en Copyright © 2011 Lees-Green, Du, O’Grady, Beyder, Farrugia and Pullan. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Physiology Lees-Green, Rachel Du, Peng O’Grady, Gregory Beyder, Arthur Farrugia, Gianrico Pullan, Andrew J. Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title | Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title_full | Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title_fullStr | Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title_full_unstemmed | Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title_short | Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives |
title_sort | biophysically based modeling of the interstitial cells of cajal: current status and future perspectives |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131535/ https://www.ncbi.nlm.nih.gov/pubmed/21772822 http://dx.doi.org/10.3389/fphys.2011.00029 |
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