Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-me...

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Detalles Bibliográficos
Autores principales: De Marino, Simona, Festa, Carmen, D’Auria, Maria Valeria, Cresteil, Thierry, Debitus, Cecile, Zampella, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131564/
https://www.ncbi.nlm.nih.gov/pubmed/21747751
http://dx.doi.org/10.3390/md9061133
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author De Marino, Simona
Festa, Carmen
D’Auria, Maria Valeria
Cresteil, Thierry
Debitus, Cecile
Zampella, Angela
author_facet De Marino, Simona
Festa, Carmen
D’Auria, Maria Valeria
Cresteil, Thierry
Debitus, Cecile
Zampella, Angela
author_sort De Marino, Simona
collection PubMed
description In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.
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spelling pubmed-31315642011-07-11 Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei De Marino, Simona Festa, Carmen D’Auria, Maria Valeria Cresteil, Thierry Debitus, Cecile Zampella, Angela Mar Drugs Article In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM. Molecular Diversity Preservation International 2011-06-22 /pmc/articles/PMC3131564/ /pubmed/21747751 http://dx.doi.org/10.3390/md9061133 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
De Marino, Simona
Festa, Carmen
D’Auria, Maria Valeria
Cresteil, Thierry
Debitus, Cecile
Zampella, Angela
Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title_full Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title_fullStr Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title_full_unstemmed Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title_short Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei
title_sort swinholide j, a potent cytotoxin from the marine sponge theonella swinhoei
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131564/
https://www.ncbi.nlm.nih.gov/pubmed/21747751
http://dx.doi.org/10.3390/md9061133
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