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Application of Magnetic Nanoparticles to Gene Delivery

Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as w...

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Detalles Bibliográficos
Autores principales: Kami, Daisuke, Takeda, Shogo, Itakura, Yoko, Gojo, Satoshi, Watanabe, Masatoshi, Toyoda, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131585/
https://www.ncbi.nlm.nih.gov/pubmed/21747701
http://dx.doi.org/10.3390/ijms12063705
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author Kami, Daisuke
Takeda, Shogo
Itakura, Yoko
Gojo, Satoshi
Watanabe, Masatoshi
Toyoda, Masashi
author_facet Kami, Daisuke
Takeda, Shogo
Itakura, Yoko
Gojo, Satoshi
Watanabe, Masatoshi
Toyoda, Masashi
author_sort Kami, Daisuke
collection PubMed
description Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles.
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spelling pubmed-31315852011-07-11 Application of Magnetic Nanoparticles to Gene Delivery Kami, Daisuke Takeda, Shogo Itakura, Yoko Gojo, Satoshi Watanabe, Masatoshi Toyoda, Masashi Int J Mol Sci Review Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles. Molecular Diversity Preservation International (MDPI) 2011-06-07 /pmc/articles/PMC3131585/ /pubmed/21747701 http://dx.doi.org/10.3390/ijms12063705 Text en © 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kami, Daisuke
Takeda, Shogo
Itakura, Yoko
Gojo, Satoshi
Watanabe, Masatoshi
Toyoda, Masashi
Application of Magnetic Nanoparticles to Gene Delivery
title Application of Magnetic Nanoparticles to Gene Delivery
title_full Application of Magnetic Nanoparticles to Gene Delivery
title_fullStr Application of Magnetic Nanoparticles to Gene Delivery
title_full_unstemmed Application of Magnetic Nanoparticles to Gene Delivery
title_short Application of Magnetic Nanoparticles to Gene Delivery
title_sort application of magnetic nanoparticles to gene delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131585/
https://www.ncbi.nlm.nih.gov/pubmed/21747701
http://dx.doi.org/10.3390/ijms12063705
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