Cargando…
Application of Magnetic Nanoparticles to Gene Delivery
Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as w...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131585/ https://www.ncbi.nlm.nih.gov/pubmed/21747701 http://dx.doi.org/10.3390/ijms12063705 |
_version_ | 1782207737220825088 |
---|---|
author | Kami, Daisuke Takeda, Shogo Itakura, Yoko Gojo, Satoshi Watanabe, Masatoshi Toyoda, Masashi |
author_facet | Kami, Daisuke Takeda, Shogo Itakura, Yoko Gojo, Satoshi Watanabe, Masatoshi Toyoda, Masashi |
author_sort | Kami, Daisuke |
collection | PubMed |
description | Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles. |
format | Online Article Text |
id | pubmed-3131585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-31315852011-07-11 Application of Magnetic Nanoparticles to Gene Delivery Kami, Daisuke Takeda, Shogo Itakura, Yoko Gojo, Satoshi Watanabe, Masatoshi Toyoda, Masashi Int J Mol Sci Review Nanoparticle technology is being incorporated into many areas of molecular science and biomedicine. Because nanoparticles are small enough to enter almost all areas of the body, including the circulatory system and cells, they have been and continue to be exploited for basic biomedical research as well as clinical diagnostic and therapeutic applications. For example, nanoparticles hold great promise for enabling gene therapy to reach its full potential by facilitating targeted delivery of DNA into tissues and cells. Substantial progress has been made in binding DNA to nanoparticles and controlling the behavior of these complexes. In this article, we review research on binding DNAs to nanoparticles as well as our latest study on non-viral gene delivery using polyethylenimine-coated magnetic nanoparticles. Molecular Diversity Preservation International (MDPI) 2011-06-07 /pmc/articles/PMC3131585/ /pubmed/21747701 http://dx.doi.org/10.3390/ijms12063705 Text en © 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Kami, Daisuke Takeda, Shogo Itakura, Yoko Gojo, Satoshi Watanabe, Masatoshi Toyoda, Masashi Application of Magnetic Nanoparticles to Gene Delivery |
title | Application of Magnetic Nanoparticles to Gene Delivery |
title_full | Application of Magnetic Nanoparticles to Gene Delivery |
title_fullStr | Application of Magnetic Nanoparticles to Gene Delivery |
title_full_unstemmed | Application of Magnetic Nanoparticles to Gene Delivery |
title_short | Application of Magnetic Nanoparticles to Gene Delivery |
title_sort | application of magnetic nanoparticles to gene delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131585/ https://www.ncbi.nlm.nih.gov/pubmed/21747701 http://dx.doi.org/10.3390/ijms12063705 |
work_keys_str_mv | AT kamidaisuke applicationofmagneticnanoparticlestogenedelivery AT takedashogo applicationofmagneticnanoparticlestogenedelivery AT itakurayoko applicationofmagneticnanoparticlestogenedelivery AT gojosatoshi applicationofmagneticnanoparticlestogenedelivery AT watanabemasatoshi applicationofmagneticnanoparticlestogenedelivery AT toyodamasashi applicationofmagneticnanoparticlestogenedelivery |