In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs

ABC transporters export clinically-relevant drugs and their over-expression causes multidrug resistance. In order to knock-down ABC transporters, ABCC1 and ABCC2, 13 shRNAs were developed. Four shRNA candidates were tested in vivo using self-complementary adeno-associated virus serotype 8. A strong,...

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Detalles Bibliográficos
Autores principales: Borel, Florie, van Logtenstein, Richard, Koornneef, Annemart, Maczuga, Piotr, Ritsema, Tita, Petry, Harald, van Deventer, Sander JH, Jansen, Peter LM, Konstantinova, Pavlina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Library Publishing Media 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131674/
https://www.ncbi.nlm.nih.gov/pubmed/21769296

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