Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin

[Image: see text] Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression, rendering ATX an attracti...

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Detalles Bibliográficos
Autores principales: Albers, Harald M. H. G., Hendrickx, Loes J. D., van Tol, Rob J. P., Hausmann, Jens, Perrakis, Anastassis, Ovaa, Huib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131786/
https://www.ncbi.nlm.nih.gov/pubmed/21615078
http://dx.doi.org/10.1021/jm200310q

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