The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies

Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we...

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Autores principales: Sassi, Nadia, Laadhar, Lilia, Driss, Maha, Kallel-Sellami, Meriam, Sellami, Slaheddine, Makni, Sondes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132010/
https://www.ncbi.nlm.nih.gov/pubmed/21457519
http://dx.doi.org/10.1186/ar3255
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author Sassi, Nadia
Laadhar, Lilia
Driss, Maha
Kallel-Sellami, Meriam
Sellami, Slaheddine
Makni, Sondes
author_facet Sassi, Nadia
Laadhar, Lilia
Driss, Maha
Kallel-Sellami, Meriam
Sellami, Slaheddine
Makni, Sondes
author_sort Sassi, Nadia
collection PubMed
description Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.
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spelling pubmed-31320102011-09-18 The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies Sassi, Nadia Laadhar, Lilia Driss, Maha Kallel-Sellami, Meriam Sellami, Slaheddine Makni, Sondes Arthritis Res Ther Review Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage. BioMed Central 2011 2011-03-18 /pmc/articles/PMC3132010/ /pubmed/21457519 http://dx.doi.org/10.1186/ar3255 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Sassi, Nadia
Laadhar, Lilia
Driss, Maha
Kallel-Sellami, Meriam
Sellami, Slaheddine
Makni, Sondes
The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title_full The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title_fullStr The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title_full_unstemmed The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title_short The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
title_sort role of the notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132010/
https://www.ncbi.nlm.nih.gov/pubmed/21457519
http://dx.doi.org/10.1186/ar3255
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