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Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagnosis and aggressive treatment to control disease activity offers the highest likelihood of...

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Autores principales: Karsdal, Morten A, Woodworth, Thasia, Henriksen, Kim, Maksymowych, Walter P, Genant, Harry, Vergnaud, Philippe, Christiansen, Claus, Schubert, Tanja, Qvist, Per, Schett, Georg, Platt, Adam, Bay-Jensen, Anne-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132026/
https://www.ncbi.nlm.nih.gov/pubmed/21539724
http://dx.doi.org/10.1186/ar3280
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author Karsdal, Morten A
Woodworth, Thasia
Henriksen, Kim
Maksymowych, Walter P
Genant, Harry
Vergnaud, Philippe
Christiansen, Claus
Schubert, Tanja
Qvist, Per
Schett, Georg
Platt, Adam
Bay-Jensen, Anne-Christine
author_facet Karsdal, Morten A
Woodworth, Thasia
Henriksen, Kim
Maksymowych, Walter P
Genant, Harry
Vergnaud, Philippe
Christiansen, Claus
Schubert, Tanja
Qvist, Per
Schett, Georg
Platt, Adam
Bay-Jensen, Anne-Christine
author_sort Karsdal, Morten A
collection PubMed
description Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagnosis and aggressive treatment to control disease activity offers the highest likelihood of preserving function and preventing disability. Joint inflammation is characterized by synovitis, osteitis, and/or peri-articular osteopenia, often accompanied by development of subchondral bone erosions, as well as progressive joint space narrowing. Biochemical markers of joint cartilage and bone degradation may enable timely detection and assessment of ongoing joint damage, and their use in facilitating treatment strategies is under investigation. Early detection of joint damage may be assisted by the characterization of biochemical markers that identify patients whose joint damage is progressing rapidly and who are thus most in need of aggressive treatment, and that, alone or in combination, identify those individuals who are likely to respond best to a potential treatment, both in terms of limiting joint damage and relieving symptoms. The aims of this review are to describe currently available biochemical markers of joint metabolism in relation to the pathobiology of joint damage and systemic bone loss in RA; to assess the limitations of, and need for additional, novel biochemical markers in RA and other rheumatic diseases, and the strategies used for assay development; and to examine the feasibility of advancement of personalized health care using biochemical markers to select therapeutic agents to which a patient is most likely to respond.
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spelling pubmed-31320262011-10-28 Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities Karsdal, Morten A Woodworth, Thasia Henriksen, Kim Maksymowych, Walter P Genant, Harry Vergnaud, Philippe Christiansen, Claus Schubert, Tanja Qvist, Per Schett, Georg Platt, Adam Bay-Jensen, Anne-Christine Arthritis Res Ther Review Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease associated with potentially debilitating joint inflammation, as well as altered skeletal bone metabolism and co-morbid conditions. Early diagnosis and aggressive treatment to control disease activity offers the highest likelihood of preserving function and preventing disability. Joint inflammation is characterized by synovitis, osteitis, and/or peri-articular osteopenia, often accompanied by development of subchondral bone erosions, as well as progressive joint space narrowing. Biochemical markers of joint cartilage and bone degradation may enable timely detection and assessment of ongoing joint damage, and their use in facilitating treatment strategies is under investigation. Early detection of joint damage may be assisted by the characterization of biochemical markers that identify patients whose joint damage is progressing rapidly and who are thus most in need of aggressive treatment, and that, alone or in combination, identify those individuals who are likely to respond best to a potential treatment, both in terms of limiting joint damage and relieving symptoms. The aims of this review are to describe currently available biochemical markers of joint metabolism in relation to the pathobiology of joint damage and systemic bone loss in RA; to assess the limitations of, and need for additional, novel biochemical markers in RA and other rheumatic diseases, and the strategies used for assay development; and to examine the feasibility of advancement of personalized health care using biochemical markers to select therapeutic agents to which a patient is most likely to respond. BioMed Central 2011 2011-04-28 /pmc/articles/PMC3132026/ /pubmed/21539724 http://dx.doi.org/10.1186/ar3280 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Karsdal, Morten A
Woodworth, Thasia
Henriksen, Kim
Maksymowych, Walter P
Genant, Harry
Vergnaud, Philippe
Christiansen, Claus
Schubert, Tanja
Qvist, Per
Schett, Georg
Platt, Adam
Bay-Jensen, Anne-Christine
Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title_full Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title_fullStr Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title_full_unstemmed Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title_short Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
title_sort biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132026/
https://www.ncbi.nlm.nih.gov/pubmed/21539724
http://dx.doi.org/10.1186/ar3280
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