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Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?

Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, alt...

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Autor principal: Pisetsky, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132028/
https://www.ncbi.nlm.nih.gov/pubmed/21554754
http://dx.doi.org/10.1186/ar3282
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author Pisetsky, David S
author_facet Pisetsky, David S
author_sort Pisetsky, David S
collection PubMed
description Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological disturbances in otherwise normal individuals. Like autoimmunity itself, ANA expression is more common among women than men, pointing to an important determinant of these responses. Future research will clarify the mechanisms of ANA expression and the utility of current assays as antecedent and screening biomarkers.
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spelling pubmed-31320282011-10-21 Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? Pisetsky, David S Arthritis Res Ther Editorial Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological disturbances in otherwise normal individuals. Like autoimmunity itself, ANA expression is more common among women than men, pointing to an important determinant of these responses. Future research will clarify the mechanisms of ANA expression and the utility of current assays as antecedent and screening biomarkers. BioMed Central 2011 2011-04-21 /pmc/articles/PMC3132028/ /pubmed/21554754 http://dx.doi.org/10.1186/ar3282 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Editorial
Pisetsky, David S
Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title_full Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title_fullStr Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title_full_unstemmed Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title_short Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
title_sort antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132028/
https://www.ncbi.nlm.nih.gov/pubmed/21554754
http://dx.doi.org/10.1186/ar3282
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