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Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis

INTRODUCTION: The purpose of the present study was to investigate the frequency of the PTPN22 +1858 C/T single nucleotide polymorphism (SNP) (rs 2476601), previously shown to be associated with several autoimmune diseases, in patients with psoriatic arthritis (PsA) in comparison with population base...

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Autores principales: Juneblad, Kristina, Johansson, Martin, Rantapää-Dahlqvist, Solbritt, Alenius, Gerd-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132030/
https://www.ncbi.nlm.nih.gov/pubmed/21410964
http://dx.doi.org/10.1186/ar3284
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author Juneblad, Kristina
Johansson, Martin
Rantapää-Dahlqvist, Solbritt
Alenius, Gerd-Marie
author_facet Juneblad, Kristina
Johansson, Martin
Rantapää-Dahlqvist, Solbritt
Alenius, Gerd-Marie
author_sort Juneblad, Kristina
collection PubMed
description INTRODUCTION: The purpose of the present study was to investigate the frequency of the PTPN22 +1858 C/T single nucleotide polymorphism (SNP) (rs 2476601), previously shown to be associated with several autoimmune diseases, in patients with psoriatic arthritis (PsA) in comparison with population based controls. METHODS: A total of 291 patients (145 male/146 female, mean age (± S.D.) 52.2 (± 13.1) years) with PsA were examined clinically, by standard laboratory tests and their DNA was genotyped for the SNP rs2476601 (PTPN22 +1858 C/T). Allelic frequencies were determined and compared with 725 controls. RESULTS: Carriage of the risk allele, PTPN22+1858T, showed a significant association with patients with PsA compared with controls (χ(2 )= 6.56, P = 0.010, odds ratio (OR) 1.49; 95% confidence interval (CI) 1.10 to 2.02). A significantly higher proportion of carriers of the risk allele (T) had significantly more deformed joints (n ± SEM) (5.9 ± 1.2 vs 2.8 ± 0.5; P = 0.005). CONCLUSIONS: In this study the +1858T allele of the PTPN22 gene, known to be associated with several autoimmune diseases, was associated with PsA. The finding of significantly more joints with deformities among carriers of the T variant could indicate a more aggressive phenotype of disease.
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spelling pubmed-31320302011-07-09 Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis Juneblad, Kristina Johansson, Martin Rantapää-Dahlqvist, Solbritt Alenius, Gerd-Marie Arthritis Res Ther Research Article INTRODUCTION: The purpose of the present study was to investigate the frequency of the PTPN22 +1858 C/T single nucleotide polymorphism (SNP) (rs 2476601), previously shown to be associated with several autoimmune diseases, in patients with psoriatic arthritis (PsA) in comparison with population based controls. METHODS: A total of 291 patients (145 male/146 female, mean age (± S.D.) 52.2 (± 13.1) years) with PsA were examined clinically, by standard laboratory tests and their DNA was genotyped for the SNP rs2476601 (PTPN22 +1858 C/T). Allelic frequencies were determined and compared with 725 controls. RESULTS: Carriage of the risk allele, PTPN22+1858T, showed a significant association with patients with PsA compared with controls (χ(2 )= 6.56, P = 0.010, odds ratio (OR) 1.49; 95% confidence interval (CI) 1.10 to 2.02). A significantly higher proportion of carriers of the risk allele (T) had significantly more deformed joints (n ± SEM) (5.9 ± 1.2 vs 2.8 ± 0.5; P = 0.005). CONCLUSIONS: In this study the +1858T allele of the PTPN22 gene, known to be associated with several autoimmune diseases, was associated with PsA. The finding of significantly more joints with deformities among carriers of the T variant could indicate a more aggressive phenotype of disease. BioMed Central 2011 2011-03-16 /pmc/articles/PMC3132030/ /pubmed/21410964 http://dx.doi.org/10.1186/ar3284 Text en Copyright ©2011 Juneblad et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Juneblad, Kristina
Johansson, Martin
Rantapää-Dahlqvist, Solbritt
Alenius, Gerd-Marie
Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title_full Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title_fullStr Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title_full_unstemmed Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title_short Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
title_sort association between the ptpn22 +1858 c/t polymorphism and psoriatic arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132030/
https://www.ncbi.nlm.nih.gov/pubmed/21410964
http://dx.doi.org/10.1186/ar3284
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