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Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy cont...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132038/ https://www.ncbi.nlm.nih.gov/pubmed/21429233 http://dx.doi.org/10.1186/ar3292 |
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author | Kang, Eun Ha Kim, Jeong Yeon Takeuchi, Fujio Kim, Joon Wan Shin, Kichul Lee, Eun Young Lee, Yun Jong Lee, Eun Bong Park, Myoung Hee Song, Yeong Wook |
author_facet | Kang, Eun Ha Kim, Jeong Yeon Takeuchi, Fujio Kim, Joon Wan Shin, Kichul Lee, Eun Young Lee, Yun Jong Lee, Eun Bong Park, Myoung Hee Song, Yeong Wook |
author_sort | Kang, Eun Ha |
collection | PubMed |
description | INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls. RESULTS: The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc <0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048). CONCLUSIONS: HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively. |
format | Online Article Text |
id | pubmed-3132038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31320382011-07-09 Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease Kang, Eun Ha Kim, Jeong Yeon Takeuchi, Fujio Kim, Joon Wan Shin, Kichul Lee, Eun Young Lee, Yun Jong Lee, Eun Bong Park, Myoung Hee Song, Yeong Wook Arthritis Res Ther Research Article INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls. RESULTS: The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc <0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048). CONCLUSIONS: HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively. BioMed Central 2011 2011-03-24 /pmc/articles/PMC3132038/ /pubmed/21429233 http://dx.doi.org/10.1186/ar3292 Text en Copyright ©2011 Kang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kang, Eun Ha Kim, Jeong Yeon Takeuchi, Fujio Kim, Joon Wan Shin, Kichul Lee, Eun Young Lee, Yun Jong Lee, Eun Bong Park, Myoung Hee Song, Yeong Wook Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title | Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title_full | Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title_fullStr | Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title_full_unstemmed | Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title_short | Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease |
title_sort | associations between the hla-a polymorphism and the clinical manifestations of behcet's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132038/ https://www.ncbi.nlm.nih.gov/pubmed/21429233 http://dx.doi.org/10.1186/ar3292 |
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