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Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease

INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy cont...

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Autores principales: Kang, Eun Ha, Kim, Jeong Yeon, Takeuchi, Fujio, Kim, Joon Wan, Shin, Kichul, Lee, Eun Young, Lee, Yun Jong, Lee, Eun Bong, Park, Myoung Hee, Song, Yeong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132038/
https://www.ncbi.nlm.nih.gov/pubmed/21429233
http://dx.doi.org/10.1186/ar3292
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author Kang, Eun Ha
Kim, Jeong Yeon
Takeuchi, Fujio
Kim, Joon Wan
Shin, Kichul
Lee, Eun Young
Lee, Yun Jong
Lee, Eun Bong
Park, Myoung Hee
Song, Yeong Wook
author_facet Kang, Eun Ha
Kim, Jeong Yeon
Takeuchi, Fujio
Kim, Joon Wan
Shin, Kichul
Lee, Eun Young
Lee, Yun Jong
Lee, Eun Bong
Park, Myoung Hee
Song, Yeong Wook
author_sort Kang, Eun Ha
collection PubMed
description INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls. RESULTS: The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc <0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048). CONCLUSIONS: HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively.
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spelling pubmed-31320382011-07-09 Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease Kang, Eun Ha Kim, Jeong Yeon Takeuchi, Fujio Kim, Joon Wan Shin, Kichul Lee, Eun Young Lee, Yun Jong Lee, Eun Bong Park, Myoung Hee Song, Yeong Wook Arthritis Res Ther Research Article INTRODUCTION: The objective was to investigate associations between the HLA-A gene and Behcet's disease (BD) and its clinical manifestations. METHODS: Genotyping for the HLA-A locus was performed using the polymerase chain reaction-Luminex typing method in 223 BD patients and 1,398 healthy controls. RESULTS: The phenotypic frequencies of HLA-A*02:07 (odds ratio (OR) = 2.03, P = 0.002), A*26:01 (OR = 1.85, P = 0.008), and A*30:04 (OR = 2.51, P = 0.006) tended to be higher in BD patients than in normal controls, but the frequency of A*33:03 (OR = 0.59, P = 0.003) tended to be lower in BD patients. A meta-analysis adopting our and the Japanese data confirmed the associations of HLA-A*02:07, A*26:01, and A*33:03 with BD. Furthermore, the frequencies of the HLA-A*02:07, A*26:01, and A*30:04 were significantly higher in patients with skin lesions (OR = 2.37, P < 0.0005, Pc < 0.012) and arthritis (OR = 2.32, P = 0.002, Pc = 0.048), with uveitis (OR = 3.01, P < 0.0005, Pc < 0.012), and with vascular lesions (OR = 9.80, P < 0.0005, Pc <0.012) and a positive pathergy test (OR = 4.10, P = 0.002, Pc = 0.048), respectively, than in controls. In HLA-B*51 non-carriers, these associations were also significant, being much stronger between HLA-A*26:01 and uveitis (OR = 4.19, P < 0.0005, Pc < 0.012) and between HLA-A*30:04 and vascular lesions (OR = 13.97, P < 0.00005, Pc < 0.0012). In addition, HLA-A*30:04 was associated with genital ulcers in HLA-B*51 non-carriers (OR = 3.89, P = 0.002, Pc = 0.048). CONCLUSIONS: HLA-A*02:07, A*26:01, and A*30:04 were associated with increased risk for BD, while HLA-A*33:03 with decreased risk. HLA-A*02:07, A*26:01, and A*30:04 were associated with skin lesions and arthritis, with uveitis, and with vascular lesions, genital ulcers, and a positive pathergy test, respectively. BioMed Central 2011 2011-03-24 /pmc/articles/PMC3132038/ /pubmed/21429233 http://dx.doi.org/10.1186/ar3292 Text en Copyright ©2011 Kang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kang, Eun Ha
Kim, Jeong Yeon
Takeuchi, Fujio
Kim, Joon Wan
Shin, Kichul
Lee, Eun Young
Lee, Yun Jong
Lee, Eun Bong
Park, Myoung Hee
Song, Yeong Wook
Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title_full Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title_fullStr Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title_full_unstemmed Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title_short Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease
title_sort associations between the hla-a polymorphism and the clinical manifestations of behcet's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132038/
https://www.ncbi.nlm.nih.gov/pubmed/21429233
http://dx.doi.org/10.1186/ar3292
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