Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

INTRODUCTION: Folate receptor (FR)-expressing macrophages have been shown to accumulate at sites of inflammation, where they promote development of inflammatory symptoms. To target such a macrophage population, we designed and evaluated the biologic activity of EC0746, a novel folic acid conjugate o...

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Detalles Bibliográficos
Autores principales: Lu, Yingjuan, Stinnette, Torian W, Westrick, Elaine, Klein, Patrick J, Gehrke, Mark A, Cross, Vicky A, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132048/
https://www.ncbi.nlm.nih.gov/pubmed/21463515
http://dx.doi.org/10.1186/ar3304

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