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Three cases of bone metastases in patients with gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresecta...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132121/ https://www.ncbi.nlm.nih.gov/pubmed/21769316 http://dx.doi.org/10.4081/rt.2011.e17 |
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author | Di Scioscio, Valerio Greco, Laura Pallotti, Maria Caterina Pantaleo, Maria Abbondanza Maleddu, Alessandra Nannini, Margherita Bazzocchi, Alberto Di Battista, Monica Mandrioli, Anna Lolli, Cristian Saponara, Maristella Giorgio, Garzillo Biasco, Guido Zompatori, Maurizio |
author_facet | Di Scioscio, Valerio Greco, Laura Pallotti, Maria Caterina Pantaleo, Maria Abbondanza Maleddu, Alessandra Nannini, Margherita Bazzocchi, Alberto Di Battista, Monica Mandrioli, Anna Lolli, Cristian Saponara, Maristella Giorgio, Garzillo Biasco, Guido Zompatori, Maurizio |
author_sort | Di Scioscio, Valerio |
collection | PubMed |
description | Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients. |
format | Online Article Text |
id | pubmed-3132121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | PAGEPress Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31321212011-07-18 Three cases of bone metastases in patients with gastrointestinal stromal tumors Di Scioscio, Valerio Greco, Laura Pallotti, Maria Caterina Pantaleo, Maria Abbondanza Maleddu, Alessandra Nannini, Margherita Bazzocchi, Alberto Di Battista, Monica Mandrioli, Anna Lolli, Cristian Saponara, Maristella Giorgio, Garzillo Biasco, Guido Zompatori, Maurizio Rare Tumors Case Report Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib) are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age), and one man (62 years of age). Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients. PAGEPress Publications 2011-04-04 /pmc/articles/PMC3132121/ /pubmed/21769316 http://dx.doi.org/10.4081/rt.2011.e17 Text en ©Copyright Di Scioscio et al., 2011 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy |
spellingShingle | Case Report Di Scioscio, Valerio Greco, Laura Pallotti, Maria Caterina Pantaleo, Maria Abbondanza Maleddu, Alessandra Nannini, Margherita Bazzocchi, Alberto Di Battista, Monica Mandrioli, Anna Lolli, Cristian Saponara, Maristella Giorgio, Garzillo Biasco, Guido Zompatori, Maurizio Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title_full | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title_fullStr | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title_full_unstemmed | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title_short | Three cases of bone metastases in patients with gastrointestinal stromal tumors |
title_sort | three cases of bone metastases in patients with gastrointestinal stromal tumors |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132121/ https://www.ncbi.nlm.nih.gov/pubmed/21769316 http://dx.doi.org/10.4081/rt.2011.e17 |
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