XCI in preimplantation mouse and human embryos: first there is remodelling…

Female eutherians silence one of their X chromosomes to accomplish an equal dose of X-linked gene expression compared with males. The mouse is the most widely used animal model in XCI research and has proven to be of great significance for understanding the complex mechanism of X-linked dosage compe...

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Autores principales: van den Berg, I. M., Galjaard, R. J., Laven, J. S. E., van Doorninck, J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132436/
https://www.ncbi.nlm.nih.gov/pubmed/21647603
http://dx.doi.org/10.1007/s00439-011-1014-9
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author van den Berg, I. M.
Galjaard, R. J.
Laven, J. S. E.
van Doorninck, J. H.
author_facet van den Berg, I. M.
Galjaard, R. J.
Laven, J. S. E.
van Doorninck, J. H.
author_sort van den Berg, I. M.
collection PubMed
description Female eutherians silence one of their X chromosomes to accomplish an equal dose of X-linked gene expression compared with males. The mouse is the most widely used animal model in XCI research and has proven to be of great significance for understanding the complex mechanism of X-linked dosage compensation. Although the basic principles of XCI are similar in mouse and humans, differences exist in the timing of XCI initiation, the genetic elements involved in XCI regulation and the form of XCI in specific tissues. Therefore, the mouse has its limitations as a model to understand early human XCI and analysis of human tissues is required. In this review, we describe these differences with respect to initiation of XCI in human and mouse preimplantation embryos, the extra-embryonic tissues and the in vitro model of the epiblast: the embryonic stem cells.
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spelling pubmed-31324362011-08-10 XCI in preimplantation mouse and human embryos: first there is remodelling… van den Berg, I. M. Galjaard, R. J. Laven, J. S. E. van Doorninck, J. H. Hum Genet Review Paper Female eutherians silence one of their X chromosomes to accomplish an equal dose of X-linked gene expression compared with males. The mouse is the most widely used animal model in XCI research and has proven to be of great significance for understanding the complex mechanism of X-linked dosage compensation. Although the basic principles of XCI are similar in mouse and humans, differences exist in the timing of XCI initiation, the genetic elements involved in XCI regulation and the form of XCI in specific tissues. Therefore, the mouse has its limitations as a model to understand early human XCI and analysis of human tissues is required. In this review, we describe these differences with respect to initiation of XCI in human and mouse preimplantation embryos, the extra-embryonic tissues and the in vitro model of the epiblast: the embryonic stem cells. Springer-Verlag 2011-06-07 2011 /pmc/articles/PMC3132436/ /pubmed/21647603 http://dx.doi.org/10.1007/s00439-011-1014-9 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Paper
van den Berg, I. M.
Galjaard, R. J.
Laven, J. S. E.
van Doorninck, J. H.
XCI in preimplantation mouse and human embryos: first there is remodelling…
title XCI in preimplantation mouse and human embryos: first there is remodelling…
title_full XCI in preimplantation mouse and human embryos: first there is remodelling…
title_fullStr XCI in preimplantation mouse and human embryos: first there is remodelling…
title_full_unstemmed XCI in preimplantation mouse and human embryos: first there is remodelling…
title_short XCI in preimplantation mouse and human embryos: first there is remodelling…
title_sort xci in preimplantation mouse and human embryos: first there is remodelling…
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132436/
https://www.ncbi.nlm.nih.gov/pubmed/21647603
http://dx.doi.org/10.1007/s00439-011-1014-9
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