Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (gen...

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Autores principales: Galy, Olivier, Chemin, Isabelle, Le Roux, Emilie, Villar, Stéphanie, Le Calvez-Kelm, Florence, Lereau, Myriam, Gouas, Doriane, Vieco, Beatriz, Suarez, Iris, Navas, Maria-Cristina, Chevallier, Michèle, Norder, Helene, Srivatanakul, Petcharin, Karalak, Anant, Sangrajrang, Suleeporn, Trépo, Christian, Hainaut, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132492/
https://www.ncbi.nlm.nih.gov/pubmed/21760996
http://dx.doi.org/10.1155/2011/697162
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author Galy, Olivier
Chemin, Isabelle
Le Roux, Emilie
Villar, Stéphanie
Le Calvez-Kelm, Florence
Lereau, Myriam
Gouas, Doriane
Vieco, Beatriz
Suarez, Iris
Navas, Maria-Cristina
Chevallier, Michèle
Norder, Helene
Srivatanakul, Petcharin
Karalak, Anant
Sangrajrang, Suleeporn
Trépo, Christian
Hainaut, Pierre
author_facet Galy, Olivier
Chemin, Isabelle
Le Roux, Emilie
Villar, Stéphanie
Le Calvez-Kelm, Florence
Lereau, Myriam
Gouas, Doriane
Vieco, Beatriz
Suarez, Iris
Navas, Maria-Cristina
Chevallier, Michèle
Norder, Helene
Srivatanakul, Petcharin
Karalak, Anant
Sangrajrang, Suleeporn
Trépo, Christian
Hainaut, Pierre
author_sort Galy, Olivier
collection PubMed
description Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.
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spelling pubmed-31324922011-07-14 Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand Galy, Olivier Chemin, Isabelle Le Roux, Emilie Villar, Stéphanie Le Calvez-Kelm, Florence Lereau, Myriam Gouas, Doriane Vieco, Beatriz Suarez, Iris Navas, Maria-Cristina Chevallier, Michèle Norder, Helene Srivatanakul, Petcharin Karalak, Anant Sangrajrang, Suleeporn Trépo, Christian Hainaut, Pierre Hepat Res Treat Research Article Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. Hindawi Publishing Corporation 2011 2011-06-30 /pmc/articles/PMC3132492/ /pubmed/21760996 http://dx.doi.org/10.1155/2011/697162 Text en Copyright © 2011 Olivier Galy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Galy, Olivier
Chemin, Isabelle
Le Roux, Emilie
Villar, Stéphanie
Le Calvez-Kelm, Florence
Lereau, Myriam
Gouas, Doriane
Vieco, Beatriz
Suarez, Iris
Navas, Maria-Cristina
Chevallier, Michèle
Norder, Helene
Srivatanakul, Petcharin
Karalak, Anant
Sangrajrang, Suleeporn
Trépo, Christian
Hainaut, Pierre
Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title_full Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title_fullStr Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title_full_unstemmed Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title_short Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand
title_sort mutations in tp53 and ctnnb1 in relation to hepatitis b and c infections in hepatocellular carcinomas from thailand
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132492/
https://www.ncbi.nlm.nih.gov/pubmed/21760996
http://dx.doi.org/10.1155/2011/697162
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