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Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions

Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect c...

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Autores principales: Nakashima, Izumi, Kawamoto, Yoshiyuki, Takeda, Kozue, Kato, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132499/
https://www.ncbi.nlm.nih.gov/pubmed/21755044
http://dx.doi.org/10.4061/2011/896567
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author Nakashima, Izumi
Kawamoto, Yoshiyuki
Takeda, Kozue
Kato, Masashi
author_facet Nakashima, Izumi
Kawamoto, Yoshiyuki
Takeda, Kozue
Kato, Masashi
author_sort Nakashima, Izumi
collection PubMed
description Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect cell surface receptors and cell membrane lipid rafts, and they induce generation of reactive oxygen species (ROS) in cells. ROS thus generated might upregulate the catalytic activities of PTKs through inactivating protein tyrosine phosphatases that dephosphorylate and inactivate autophosphorylated PTKs. Recent evidence has, however, demonstrated that ROS could also directly oxidize SH groups of genetically conserved specific cysteines on PTKs, sometimes producing disulfide-bonded dimers of PTK proteins, either for upregulation or downregulation of their catalytic activities. The basic role of the redox reaction/covalent bond-mediated modification of protein tertiary structure-linked noncovalent bond-oriented signaling systems in living organisms is discussed.
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spelling pubmed-31324992011-07-13 Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions Nakashima, Izumi Kawamoto, Yoshiyuki Takeda, Kozue Kato, Masashi Enzyme Res Review Article Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect cell surface receptors and cell membrane lipid rafts, and they induce generation of reactive oxygen species (ROS) in cells. ROS thus generated might upregulate the catalytic activities of PTKs through inactivating protein tyrosine phosphatases that dephosphorylate and inactivate autophosphorylated PTKs. Recent evidence has, however, demonstrated that ROS could also directly oxidize SH groups of genetically conserved specific cysteines on PTKs, sometimes producing disulfide-bonded dimers of PTK proteins, either for upregulation or downregulation of their catalytic activities. The basic role of the redox reaction/covalent bond-mediated modification of protein tertiary structure-linked noncovalent bond-oriented signaling systems in living organisms is discussed. SAGE-Hindawi Access to Research 2011-06-26 /pmc/articles/PMC3132499/ /pubmed/21755044 http://dx.doi.org/10.4061/2011/896567 Text en Copyright © 2011 Izumi Nakashima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nakashima, Izumi
Kawamoto, Yoshiyuki
Takeda, Kozue
Kato, Masashi
Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title_full Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title_fullStr Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title_full_unstemmed Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title_short Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
title_sort control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132499/
https://www.ncbi.nlm.nih.gov/pubmed/21755044
http://dx.doi.org/10.4061/2011/896567
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