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Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132499/ https://www.ncbi.nlm.nih.gov/pubmed/21755044 http://dx.doi.org/10.4061/2011/896567 |
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author | Nakashima, Izumi Kawamoto, Yoshiyuki Takeda, Kozue Kato, Masashi |
author_facet | Nakashima, Izumi Kawamoto, Yoshiyuki Takeda, Kozue Kato, Masashi |
author_sort | Nakashima, Izumi |
collection | PubMed |
description | Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect cell surface receptors and cell membrane lipid rafts, and they induce generation of reactive oxygen species (ROS) in cells. ROS thus generated might upregulate the catalytic activities of PTKs through inactivating protein tyrosine phosphatases that dephosphorylate and inactivate autophosphorylated PTKs. Recent evidence has, however, demonstrated that ROS could also directly oxidize SH groups of genetically conserved specific cysteines on PTKs, sometimes producing disulfide-bonded dimers of PTK proteins, either for upregulation or downregulation of their catalytic activities. The basic role of the redox reaction/covalent bond-mediated modification of protein tertiary structure-linked noncovalent bond-oriented signaling systems in living organisms is discussed. |
format | Online Article Text |
id | pubmed-3132499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31324992011-07-13 Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions Nakashima, Izumi Kawamoto, Yoshiyuki Takeda, Kozue Kato, Masashi Enzyme Res Review Article Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs). The environment-linked redox reactions seem to primarily affect cell surface receptors and cell membrane lipid rafts, and they induce generation of reactive oxygen species (ROS) in cells. ROS thus generated might upregulate the catalytic activities of PTKs through inactivating protein tyrosine phosphatases that dephosphorylate and inactivate autophosphorylated PTKs. Recent evidence has, however, demonstrated that ROS could also directly oxidize SH groups of genetically conserved specific cysteines on PTKs, sometimes producing disulfide-bonded dimers of PTK proteins, either for upregulation or downregulation of their catalytic activities. The basic role of the redox reaction/covalent bond-mediated modification of protein tertiary structure-linked noncovalent bond-oriented signaling systems in living organisms is discussed. SAGE-Hindawi Access to Research 2011-06-26 /pmc/articles/PMC3132499/ /pubmed/21755044 http://dx.doi.org/10.4061/2011/896567 Text en Copyright © 2011 Izumi Nakashima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nakashima, Izumi Kawamoto, Yoshiyuki Takeda, Kozue Kato, Masashi Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title | Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title_full | Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title_fullStr | Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title_full_unstemmed | Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title_short | Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions |
title_sort | control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132499/ https://www.ncbi.nlm.nih.gov/pubmed/21755044 http://dx.doi.org/10.4061/2011/896567 |
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