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Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of recep...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132527/ https://www.ncbi.nlm.nih.gov/pubmed/21765832 http://dx.doi.org/10.1155/2011/246954 |
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author | Delom, Frederic Fessart, Delphine |
author_facet | Delom, Frederic Fessart, Delphine |
author_sort | Delom, Frederic |
collection | PubMed |
description | The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle. |
format | Online Article Text |
id | pubmed-3132527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31325272011-07-15 Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR Delom, Frederic Fessart, Delphine Int J Cell Biol Review Article The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle. Hindawi Publishing Corporation 2011 2011-06-07 /pmc/articles/PMC3132527/ /pubmed/21765832 http://dx.doi.org/10.1155/2011/246954 Text en Copyright © 2011 F. Delom and D. Fessart. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Delom, Frederic Fessart, Delphine Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title | Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title_full | Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title_fullStr | Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title_full_unstemmed | Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title_short | Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR |
title_sort | role of phosphorylation in the control of clathrin-mediated internalization of gpcr |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132527/ https://www.ncbi.nlm.nih.gov/pubmed/21765832 http://dx.doi.org/10.1155/2011/246954 |
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