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Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR

The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of recep...

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Detalles Bibliográficos
Autores principales: Delom, Frederic, Fessart, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132527/
https://www.ncbi.nlm.nih.gov/pubmed/21765832
http://dx.doi.org/10.1155/2011/246954
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author Delom, Frederic
Fessart, Delphine
author_facet Delom, Frederic
Fessart, Delphine
author_sort Delom, Frederic
collection PubMed
description The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle.
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spelling pubmed-31325272011-07-15 Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR Delom, Frederic Fessart, Delphine Int J Cell Biol Review Article The process by which G protein-coupled receptors (GPCRs) are internalized through the clathrin-coated vesicles involves interactions of multifunctional adaptor proteins. These interactions are tightly controlled by phosphorylation and dephosphorylation mechanisms resulting in the regulation of receptor endocytosis. However, the identities of the kinases involved in this process remained largely unknown until recently. This paper discusses advances in our knowledge of the important role played by protein phosphorylation in the regulation of the endocytic machinery and how phosphorylation controls the coated vesicle cycle. Hindawi Publishing Corporation 2011 2011-06-07 /pmc/articles/PMC3132527/ /pubmed/21765832 http://dx.doi.org/10.1155/2011/246954 Text en Copyright © 2011 F. Delom and D. Fessart. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Delom, Frederic
Fessart, Delphine
Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title_full Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title_fullStr Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title_full_unstemmed Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title_short Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR
title_sort role of phosphorylation in the control of clathrin-mediated internalization of gpcr
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132527/
https://www.ncbi.nlm.nih.gov/pubmed/21765832
http://dx.doi.org/10.1155/2011/246954
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