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Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia

Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jo...

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Autores principales: Zhang, Yu, Schuff, Norbert, Ching, Christopher, Tosun, Duygu, Zhan, Wang, Nezamzadeh, Marzieh, Rosen, Howard J., Kramer, Joel H., Gorno-Tempini, Maria Luisa, Miller, Bruce L., Weiner, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132541/
https://www.ncbi.nlm.nih.gov/pubmed/21760989
http://dx.doi.org/10.4061/2011/546871
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author Zhang, Yu
Schuff, Norbert
Ching, Christopher
Tosun, Duygu
Zhan, Wang
Nezamzadeh, Marzieh
Rosen, Howard J.
Kramer, Joel H.
Gorno-Tempini, Maria Luisa
Miller, Bruce L.
Weiner, Michael W.
author_facet Zhang, Yu
Schuff, Norbert
Ching, Christopher
Tosun, Duygu
Zhan, Wang
Nezamzadeh, Marzieh
Rosen, Howard J.
Kramer, Joel H.
Gorno-Tempini, Maria Luisa
Miller, Bruce L.
Weiner, Michael W.
author_sort Zhang, Yu
collection PubMed
description Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jointly to elucidate differences in abnormal MRI patterns between the diseases. Twenty AD, 20 FTD patients, and 21 healthy control subjects were imaged using a 4 Tesla MRI. GM loss and GM hypoperfusion were measured using high-resolution T1 and arterial spin labeling MRI (ASL-MRI). WM degradation was measured with diffusion tensor imaging (DTI). Using a new analytical approach, the study found greater WM degenerations in FTD than AD at mild abnormality levels. Furthermore, the GM loss and WM degeneration exceeded the reduced perfusion in FTD whereas, in AD, structural and functional damages were similar. Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD.
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spelling pubmed-31325412011-07-14 Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia Zhang, Yu Schuff, Norbert Ching, Christopher Tosun, Duygu Zhan, Wang Nezamzadeh, Marzieh Rosen, Howard J. Kramer, Joel H. Gorno-Tempini, Maria Luisa Miller, Bruce L. Weiner, Michael W. Int J Alzheimers Dis Research Article Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jointly to elucidate differences in abnormal MRI patterns between the diseases. Twenty AD, 20 FTD patients, and 21 healthy control subjects were imaged using a 4 Tesla MRI. GM loss and GM hypoperfusion were measured using high-resolution T1 and arterial spin labeling MRI (ASL-MRI). WM degradation was measured with diffusion tensor imaging (DTI). Using a new analytical approach, the study found greater WM degenerations in FTD than AD at mild abnormality levels. Furthermore, the GM loss and WM degeneration exceeded the reduced perfusion in FTD whereas, in AD, structural and functional damages were similar. Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD. SAGE-Hindawi Access to Research 2011-06-27 /pmc/articles/PMC3132541/ /pubmed/21760989 http://dx.doi.org/10.4061/2011/546871 Text en Copyright © 2011 Yu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Yu
Schuff, Norbert
Ching, Christopher
Tosun, Duygu
Zhan, Wang
Nezamzadeh, Marzieh
Rosen, Howard J.
Kramer, Joel H.
Gorno-Tempini, Maria Luisa
Miller, Bruce L.
Weiner, Michael W.
Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title_full Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title_fullStr Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title_full_unstemmed Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title_short Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia
title_sort joint assessment of structural, perfusion, and diffusion mri in alzheimer's disease and frontotemporal dementia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132541/
https://www.ncbi.nlm.nih.gov/pubmed/21760989
http://dx.doi.org/10.4061/2011/546871
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