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Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses

Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Di...

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Detalles Bibliográficos
Autores principales: Profumo, Elisabetta, Buttari, Brigitta, Riganò, Rachele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132615/
https://www.ncbi.nlm.nih.gov/pubmed/21755027
http://dx.doi.org/10.4061/2011/295705
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author Profumo, Elisabetta
Buttari, Brigitta
Riganò, Rachele
author_facet Profumo, Elisabetta
Buttari, Brigitta
Riganò, Rachele
author_sort Profumo, Elisabetta
collection PubMed
description Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation.
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spelling pubmed-31326152011-07-13 Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses Profumo, Elisabetta Buttari, Brigitta Riganò, Rachele Int J Inflam Review Article Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation. SAGE-Hindawi Access to Research 2011-06-28 /pmc/articles/PMC3132615/ /pubmed/21755027 http://dx.doi.org/10.4061/2011/295705 Text en Copyright © 2011 Elisabetta Profumo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Profumo, Elisabetta
Buttari, Brigitta
Riganò, Rachele
Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title_full Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title_fullStr Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title_full_unstemmed Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title_short Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
title_sort oxidative stress in cardiovascular inflammation: its involvement in autoimmune responses
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132615/
https://www.ncbi.nlm.nih.gov/pubmed/21755027
http://dx.doi.org/10.4061/2011/295705
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