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Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses
Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Di...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132615/ https://www.ncbi.nlm.nih.gov/pubmed/21755027 http://dx.doi.org/10.4061/2011/295705 |
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author | Profumo, Elisabetta Buttari, Brigitta Riganò, Rachele |
author_facet | Profumo, Elisabetta Buttari, Brigitta Riganò, Rachele |
author_sort | Profumo, Elisabetta |
collection | PubMed |
description | Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation. |
format | Online Article Text |
id | pubmed-3132615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31326152011-07-13 Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses Profumo, Elisabetta Buttari, Brigitta Riganò, Rachele Int J Inflam Review Article Recently, it has become clear that atherosclerosis is a chronic inflammatory disease in which inflammation and immune responses play a key role. Accelerated atherosclerosis has been reported in patients with autoimmune diseases, suggesting an involvement of autoimmune mechanisms in atherogenesis. Different self-antigens or modified self-molecules have been identified as target of humoral and cellular immune responses in patients with atherosclerotic disease. Oxidative stress, increasingly reported in these patients, is the major event causing structural modification of proteins with consequent appearance of neoepitopes. Self-molecules modified by oxidative events can become targets of autoimmune reactions, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper, we will summarize the best characterized autoantigens in atherosclerosis and their possible role in cardiovascular inflammation. SAGE-Hindawi Access to Research 2011-06-28 /pmc/articles/PMC3132615/ /pubmed/21755027 http://dx.doi.org/10.4061/2011/295705 Text en Copyright © 2011 Elisabetta Profumo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Profumo, Elisabetta Buttari, Brigitta Riganò, Rachele Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title_full | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title_fullStr | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title_full_unstemmed | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title_short | Oxidative Stress in Cardiovascular Inflammation: Its Involvement in Autoimmune Responses |
title_sort | oxidative stress in cardiovascular inflammation: its involvement in autoimmune responses |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132615/ https://www.ncbi.nlm.nih.gov/pubmed/21755027 http://dx.doi.org/10.4061/2011/295705 |
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