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Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients

Objectives. Epithelial mesenchymal transition (EMT) is important for peritoneal deterioration. We evaluated the association between peritoneal solute transport rate (PSTR) and effluent markers related to EMT with adjusted values for effluent cancer antigen 125 (CA125). Methods. One hundred five inci...

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Autores principales: Mizuiri, Sonoo, Hemmi, Hiromichi, Arita, Michitsune, Tai, Reibin, Hattori, Yoshinari, Muto, Atsuhiko, Suzuki, Yasunori, Ohashi, Yasushi, Sakai, Ken, Aikawa, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132654/
https://www.ncbi.nlm.nih.gov/pubmed/21755056
http://dx.doi.org/10.4061/2011/261040
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author Mizuiri, Sonoo
Hemmi, Hiromichi
Arita, Michitsune
Tai, Reibin
Hattori, Yoshinari
Muto, Atsuhiko
Suzuki, Yasunori
Ohashi, Yasushi
Sakai, Ken
Aikawa, Atsushi
author_facet Mizuiri, Sonoo
Hemmi, Hiromichi
Arita, Michitsune
Tai, Reibin
Hattori, Yoshinari
Muto, Atsuhiko
Suzuki, Yasunori
Ohashi, Yasushi
Sakai, Ken
Aikawa, Atsushi
author_sort Mizuiri, Sonoo
collection PubMed
description Objectives. Epithelial mesenchymal transition (EMT) is important for peritoneal deterioration. We evaluated the association between peritoneal solute transport rate (PSTR) and effluent markers related to EMT with adjusted values for effluent cancer antigen 125 (CA125). Methods. One hundred five incident peritoneal dialysis (PD) patients on PD for 25 (12–68) months with biocompatible solutions were included in the study. Fast peritoneal equilibration test was used to evaluate PSTR. Effluent hepatocyte growth factor (HGF), bone morphogenic protein-7 (BMP-7), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and CA125 at 4 h were measured. Results. Patients with dialysate/plasma creatinine ≧0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Conclusion. Increase in the effluent HGF levels as a compensatory mechanism is a marker of peritoneal deterioration, but controversy remains regarding adjusted value for CA125.
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spelling pubmed-31326542011-07-13 Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients Mizuiri, Sonoo Hemmi, Hiromichi Arita, Michitsune Tai, Reibin Hattori, Yoshinari Muto, Atsuhiko Suzuki, Yasunori Ohashi, Yasushi Sakai, Ken Aikawa, Atsushi Int J Nephrol Clinical Study Objectives. Epithelial mesenchymal transition (EMT) is important for peritoneal deterioration. We evaluated the association between peritoneal solute transport rate (PSTR) and effluent markers related to EMT with adjusted values for effluent cancer antigen 125 (CA125). Methods. One hundred five incident peritoneal dialysis (PD) patients on PD for 25 (12–68) months with biocompatible solutions were included in the study. Fast peritoneal equilibration test was used to evaluate PSTR. Effluent hepatocyte growth factor (HGF), bone morphogenic protein-7 (BMP-7), vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and CA125 at 4 h were measured. Results. Patients with dialysate/plasma creatinine ≧0.82 showed significantly higher effluent HGF (240 versus 133 pg/mL, P < .001), VEGF, IL-6, and IL6/CA125 levels than the others but no significant differences in effluent HGF/CA125, BMP-7, and BMP7/CA125 were observed. Conclusion. Increase in the effluent HGF levels as a compensatory mechanism is a marker of peritoneal deterioration, but controversy remains regarding adjusted value for CA125. SAGE-Hindawi Access to Research 2011-07-06 /pmc/articles/PMC3132654/ /pubmed/21755056 http://dx.doi.org/10.4061/2011/261040 Text en Copyright © 2011 Sonoo Mizuiri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Mizuiri, Sonoo
Hemmi, Hiromichi
Arita, Michitsune
Tai, Reibin
Hattori, Yoshinari
Muto, Atsuhiko
Suzuki, Yasunori
Ohashi, Yasushi
Sakai, Ken
Aikawa, Atsushi
Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title_full Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title_fullStr Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title_full_unstemmed Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title_short Effluent Markers Related to Epithelial Mesenchymal Transition with Adjusted Values for Effluent Cancer Antigen 125 in Peritoneal Dialysis Patients
title_sort effluent markers related to epithelial mesenchymal transition with adjusted values for effluent cancer antigen 125 in peritoneal dialysis patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132654/
https://www.ncbi.nlm.nih.gov/pubmed/21755056
http://dx.doi.org/10.4061/2011/261040
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