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Longitudinal study of leptin levels in chronic hemodialysis patients
BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutriti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132708/ https://www.ncbi.nlm.nih.gov/pubmed/21676262 http://dx.doi.org/10.1186/1475-2891-10-68 |
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author | Beberashvili, Ilia Sinuani, Inna Azar, Ada Yasur, Hila Feldman, Leonid Averbukh, Zhan Weissgarten, Joshua |
author_facet | Beberashvili, Ilia Sinuani, Inna Azar, Ada Yasur, Hila Feldman, Leonid Averbukh, Zhan Weissgarten, Joshua |
author_sort | Beberashvili, Ilia |
collection | PubMed |
description | BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutritional status and survival in a cohort of prevalent hemodialysis patients. METHODS: Leptin, dietary energy and protein intake, biochemical markers of nutrition and body composition (anthropometry and bioimpedance analysis) were measured at baseline and at 6, 12, 18 and 24 months following enrollment, in 101 prevalent hemodialysis patients (37% women) with a mean age of 64.6 ± 11.5 years. Observation of this cohort was continued over 2 additional years. Changes in repeated measures were evaluated, with adjustment for baseline differences in demographic and clinical parameters. RESULTS: Significant reduction of leptin levels with time were observed (linear estimate: -2.5010 ± 0.57 ng/ml/2y; p < 0.001) with a more rapid decline in leptin levels in the highest leptin tertile in both unadjusted (p = 0.007) and fully adjusted (p = 0.047) models. A significant reduction in body composition parameters over time was observed, but was not influenced by leptin (leptin-by-time interactions were not significant). No significant associations were noted between leptin levels and changes in dietary protein or energy intake, or laboratory nutritional markers. Finally, cumulative incidences of survival were unaffected by the baseline serum leptin levels. CONCLUSIONS: Thus leptin levels reflect fat mass depots, rather than independently contributing to uremic anorexia or modifying nutritional status and/or survival in chronic hemodialysis patients. The importance of such information is high if leptin is contemplated as a potential therapeutic target in hemodialysis patients. |
format | Online Article Text |
id | pubmed-3132708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31327082011-07-12 Longitudinal study of leptin levels in chronic hemodialysis patients Beberashvili, Ilia Sinuani, Inna Azar, Ada Yasur, Hila Feldman, Leonid Averbukh, Zhan Weissgarten, Joshua Nutr J Research BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutritional status and survival in a cohort of prevalent hemodialysis patients. METHODS: Leptin, dietary energy and protein intake, biochemical markers of nutrition and body composition (anthropometry and bioimpedance analysis) were measured at baseline and at 6, 12, 18 and 24 months following enrollment, in 101 prevalent hemodialysis patients (37% women) with a mean age of 64.6 ± 11.5 years. Observation of this cohort was continued over 2 additional years. Changes in repeated measures were evaluated, with adjustment for baseline differences in demographic and clinical parameters. RESULTS: Significant reduction of leptin levels with time were observed (linear estimate: -2.5010 ± 0.57 ng/ml/2y; p < 0.001) with a more rapid decline in leptin levels in the highest leptin tertile in both unadjusted (p = 0.007) and fully adjusted (p = 0.047) models. A significant reduction in body composition parameters over time was observed, but was not influenced by leptin (leptin-by-time interactions were not significant). No significant associations were noted between leptin levels and changes in dietary protein or energy intake, or laboratory nutritional markers. Finally, cumulative incidences of survival were unaffected by the baseline serum leptin levels. CONCLUSIONS: Thus leptin levels reflect fat mass depots, rather than independently contributing to uremic anorexia or modifying nutritional status and/or survival in chronic hemodialysis patients. The importance of such information is high if leptin is contemplated as a potential therapeutic target in hemodialysis patients. BioMed Central 2011-06-15 /pmc/articles/PMC3132708/ /pubmed/21676262 http://dx.doi.org/10.1186/1475-2891-10-68 Text en Copyright ©2011 Beberashvili et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Beberashvili, Ilia Sinuani, Inna Azar, Ada Yasur, Hila Feldman, Leonid Averbukh, Zhan Weissgarten, Joshua Longitudinal study of leptin levels in chronic hemodialysis patients |
title | Longitudinal study of leptin levels in chronic hemodialysis patients |
title_full | Longitudinal study of leptin levels in chronic hemodialysis patients |
title_fullStr | Longitudinal study of leptin levels in chronic hemodialysis patients |
title_full_unstemmed | Longitudinal study of leptin levels in chronic hemodialysis patients |
title_short | Longitudinal study of leptin levels in chronic hemodialysis patients |
title_sort | longitudinal study of leptin levels in chronic hemodialysis patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132708/ https://www.ncbi.nlm.nih.gov/pubmed/21676262 http://dx.doi.org/10.1186/1475-2891-10-68 |
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