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Longitudinal study of leptin levels in chronic hemodialysis patients

BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutriti...

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Autores principales: Beberashvili, Ilia, Sinuani, Inna, Azar, Ada, Yasur, Hila, Feldman, Leonid, Averbukh, Zhan, Weissgarten, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132708/
https://www.ncbi.nlm.nih.gov/pubmed/21676262
http://dx.doi.org/10.1186/1475-2891-10-68
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author Beberashvili, Ilia
Sinuani, Inna
Azar, Ada
Yasur, Hila
Feldman, Leonid
Averbukh, Zhan
Weissgarten, Joshua
author_facet Beberashvili, Ilia
Sinuani, Inna
Azar, Ada
Yasur, Hila
Feldman, Leonid
Averbukh, Zhan
Weissgarten, Joshua
author_sort Beberashvili, Ilia
collection PubMed
description BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutritional status and survival in a cohort of prevalent hemodialysis patients. METHODS: Leptin, dietary energy and protein intake, biochemical markers of nutrition and body composition (anthropometry and bioimpedance analysis) were measured at baseline and at 6, 12, 18 and 24 months following enrollment, in 101 prevalent hemodialysis patients (37% women) with a mean age of 64.6 ± 11.5 years. Observation of this cohort was continued over 2 additional years. Changes in repeated measures were evaluated, with adjustment for baseline differences in demographic and clinical parameters. RESULTS: Significant reduction of leptin levels with time were observed (linear estimate: -2.5010 ± 0.57 ng/ml/2y; p < 0.001) with a more rapid decline in leptin levels in the highest leptin tertile in both unadjusted (p = 0.007) and fully adjusted (p = 0.047) models. A significant reduction in body composition parameters over time was observed, but was not influenced by leptin (leptin-by-time interactions were not significant). No significant associations were noted between leptin levels and changes in dietary protein or energy intake, or laboratory nutritional markers. Finally, cumulative incidences of survival were unaffected by the baseline serum leptin levels. CONCLUSIONS: Thus leptin levels reflect fat mass depots, rather than independently contributing to uremic anorexia or modifying nutritional status and/or survival in chronic hemodialysis patients. The importance of such information is high if leptin is contemplated as a potential therapeutic target in hemodialysis patients.
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spelling pubmed-31327082011-07-12 Longitudinal study of leptin levels in chronic hemodialysis patients Beberashvili, Ilia Sinuani, Inna Azar, Ada Yasur, Hila Feldman, Leonid Averbukh, Zhan Weissgarten, Joshua Nutr J Research BACKGROUND: The influence of serum leptin levels on nutritional status and survival in chronic hemodialysis patients remained to be elucidated. We conducted a prospective longitudinal study of leptin levels and nutritional parameters to determine whether changes of serum leptin levels modify nutritional status and survival in a cohort of prevalent hemodialysis patients. METHODS: Leptin, dietary energy and protein intake, biochemical markers of nutrition and body composition (anthropometry and bioimpedance analysis) were measured at baseline and at 6, 12, 18 and 24 months following enrollment, in 101 prevalent hemodialysis patients (37% women) with a mean age of 64.6 ± 11.5 years. Observation of this cohort was continued over 2 additional years. Changes in repeated measures were evaluated, with adjustment for baseline differences in demographic and clinical parameters. RESULTS: Significant reduction of leptin levels with time were observed (linear estimate: -2.5010 ± 0.57 ng/ml/2y; p < 0.001) with a more rapid decline in leptin levels in the highest leptin tertile in both unadjusted (p = 0.007) and fully adjusted (p = 0.047) models. A significant reduction in body composition parameters over time was observed, but was not influenced by leptin (leptin-by-time interactions were not significant). No significant associations were noted between leptin levels and changes in dietary protein or energy intake, or laboratory nutritional markers. Finally, cumulative incidences of survival were unaffected by the baseline serum leptin levels. CONCLUSIONS: Thus leptin levels reflect fat mass depots, rather than independently contributing to uremic anorexia or modifying nutritional status and/or survival in chronic hemodialysis patients. The importance of such information is high if leptin is contemplated as a potential therapeutic target in hemodialysis patients. BioMed Central 2011-06-15 /pmc/articles/PMC3132708/ /pubmed/21676262 http://dx.doi.org/10.1186/1475-2891-10-68 Text en Copyright ©2011 Beberashvili et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Beberashvili, Ilia
Sinuani, Inna
Azar, Ada
Yasur, Hila
Feldman, Leonid
Averbukh, Zhan
Weissgarten, Joshua
Longitudinal study of leptin levels in chronic hemodialysis patients
title Longitudinal study of leptin levels in chronic hemodialysis patients
title_full Longitudinal study of leptin levels in chronic hemodialysis patients
title_fullStr Longitudinal study of leptin levels in chronic hemodialysis patients
title_full_unstemmed Longitudinal study of leptin levels in chronic hemodialysis patients
title_short Longitudinal study of leptin levels in chronic hemodialysis patients
title_sort longitudinal study of leptin levels in chronic hemodialysis patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132708/
https://www.ncbi.nlm.nih.gov/pubmed/21676262
http://dx.doi.org/10.1186/1475-2891-10-68
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