Impact of the HIV-1 env Genetic Context outside HR1–HR2 on Resistance to the Fusion Inhibitor Enfuvirtide and Viral Infectivity in Clinical Isolates

Resistance mutations to the HIV-1 fusion inhibitor enfuvirtide emerge mainly within the drug's target region, HR1, and compensatory mutations have been described within HR2. The surrounding envelope (env) genetic context might also contribute to resistance, although to what extent and through w...

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Detalles Bibliográficos
Autores principales: Baatz, Franky, Nijhuis, Monique, Lemaire, Morgane, Riedijk, Martiene, Wensing, Annemarie M. J., Servais, Jean-Yves, van Ham, Petra M., Hoepelman, Andy I. M., Koopmans, Peter P., Sprenger, Herman G., Devaux, Carole, Schmit, Jean-Claude, Perez Bercoff, Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132734/
https://www.ncbi.nlm.nih.gov/pubmed/21760896
http://dx.doi.org/10.1371/journal.pone.0021535

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