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Resistance to the CCR5 Inhibitor 5P12-RANTES Requires a Difficult Evolution from CCR5 to CXCR4 Coreceptor Use

Viral resistance to small molecule allosteric inhibitors of CCR5 is well documented, and involves either selection of preexisting CXCR4-using HIV-1 variants or envelope sequence evolution to use inhibitor-bound CCR5 for entry. Resistance to macromolecular CCR5 inhibitors has been more difficult to d...

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Detalles Bibliográficos
Autores principales:	Nedellec, Rebecca, Coetzer, Mia, Lederman, Michael M., Offord, Robin E., Hartley, Oliver, Mosier, Donald E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132774/ https://www.ncbi.nlm.nih.gov/pubmed/21760945 http://dx.doi.org/10.1371/journal.pone.0022020

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