Aberrant DNA Methylation Is Associated with Disease Progression, Resistance to Imatinib and Shortened Survival in Chronic Myelogenous Leukemia

The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not completely understood. To elucidate its role we analyzed 120 patients with CML for methylation of promoter-associated CpG islands of 10 genes. Five genes were identified by DNA methylation screening in the K562 cel...

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Detalles Bibliográficos
Autores principales: Jelinek, Jaroslav, Gharibyan, Vazganush, Estecio, Marcos R. H., Kondo, Kimie, He, Rong, Chung, Woonbok, Lu, Yue, Zhang, Nianxiang, Liang, Shoudan, Kantarjian, Hagop M., Cortes, Jorge E., Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132778/
https://www.ncbi.nlm.nih.gov/pubmed/21760961
http://dx.doi.org/10.1371/journal.pone.0022110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132778/
https://www.ncbi.nlm.nih.gov/pubmed/21760961
http://dx.doi.org/10.1371/journal.pone.0022110

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