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B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury
Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132842/ https://www.ncbi.nlm.nih.gov/pubmed/21761002 http://dx.doi.org/10.4061/2011/951629 |
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author | de Cal, Massimo Haapio, Mikko Cruz, Dinna N. Lentini, Paolo House, Andrew A. Bobek, Ilona Virzì, Grazia M. Corradi, Valentina Basso, Flavio Piccinni, Pasquale D'Angelo, Angela Chang, Jamie W. Rosner, Mitchell H. Ronco, Claudio |
author_facet | de Cal, Massimo Haapio, Mikko Cruz, Dinna N. Lentini, Paolo House, Andrew A. Bobek, Ilona Virzì, Grazia M. Corradi, Valentina Basso, Flavio Piccinni, Pasquale D'Angelo, Angela Chang, Jamie W. Rosner, Mitchell H. Ronco, Claudio |
author_sort | de Cal, Massimo |
collection | PubMed |
description | Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients. Aims. To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients. Methods. We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay. Results. For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL). Conclusion. Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation. |
format | Online Article Text |
id | pubmed-3132842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31328422011-07-14 B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury de Cal, Massimo Haapio, Mikko Cruz, Dinna N. Lentini, Paolo House, Andrew A. Bobek, Ilona Virzì, Grazia M. Corradi, Valentina Basso, Flavio Piccinni, Pasquale D'Angelo, Angela Chang, Jamie W. Rosner, Mitchell H. Ronco, Claudio Int J Nephrol Research Article Introduction. Acute kidney injury (AKI) is common in the intensive care unit (ICU) and associated with poor outcome. Plasma B-type natriuretic peptide (BNP) is a biomarker related to myocardial overload, and is elevated in some ICU patients. There is a high prevalence of both cardiac and renal dysfunction in ICU patients. Aims. To investigate whether plasma BNP levels in the first 48 hours were associated with AKI in ICU patients. Methods. We studied a cohort of 34 consecutive ICU patients. Primary outcome was presence of AKI on presentation, or during ICU stay. Results. For patients with AKI on presentation, BNP was statistically higher at 24 and 48 hours than No-AKI patients (865 versus 148 pg/mL; 1380 versus 131 pg/mL). For patients developing AKI during 48 hours, BNP was statistically higher at 0, 24 and 48 hours than No-AKI patients (510 versus 197 pg/mL; 552 versus 124 pg/mL; 949 versus 104 pg/mL). Conclusion. Critically ill patients with AKI on presentation or during ICU stay have higher levels of the cardiac biomarker BNP relative to No-AKI patients. Elevated levels of plasma BNP may help identify patients with elevated risk of AKI in the ICU setting. The mechanism for this cardiorenal connection requires further investigation. SAGE-Hindawi Access to Research 2011-06-22 /pmc/articles/PMC3132842/ /pubmed/21761002 http://dx.doi.org/10.4061/2011/951629 Text en Copyright © 2011 Massimo de Cal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article de Cal, Massimo Haapio, Mikko Cruz, Dinna N. Lentini, Paolo House, Andrew A. Bobek, Ilona Virzì, Grazia M. Corradi, Valentina Basso, Flavio Piccinni, Pasquale D'Angelo, Angela Chang, Jamie W. Rosner, Mitchell H. Ronco, Claudio B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title | B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title_full | B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title_fullStr | B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title_full_unstemmed | B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title_short | B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury |
title_sort | b-type natriuretic peptide in the critically ill with acute kidney injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132842/ https://www.ncbi.nlm.nih.gov/pubmed/21761002 http://dx.doi.org/10.4061/2011/951629 |
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