Parametric Images in Assessing Bone Grafts Using Dynamic (18)F-Fluoride PET

The early identification of graft failure would improve patient management. (18)F-fluoride is a suitable tracer for quantifying bone metabolism. Performance of parametric images constructed by Patlak graphical analysis (PGA) with various time periods was evaluated in the analysis of dynamic (18)F-fl...

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Detalles Bibliográficos
Autores principales: Wen, Lingfeng, Eberl, Stefan, Feng, (David) Dagan, Stalley, Paul, Huang, Gang, Fulham, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132866/
https://www.ncbi.nlm.nih.gov/pubmed/21755052
http://dx.doi.org/10.1155/2011/189830
Descripción
Sumario:The early identification of graft failure would improve patient management. (18)F-fluoride is a suitable tracer for quantifying bone metabolism. Performance of parametric images constructed by Patlak graphical analysis (PGA) with various time periods was evaluated in the analysis of dynamic (18)F-fluoride PET studies of eight patients with fibula bone grafts after limb salvage surgery. The PGA parametric image approach tended to underestimate influx rate. The linear portion of PGA analysis was found to be from 10 to 50 min. It shows promise in providing a quantitative assessment of the viability of bone grafts.

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