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Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thoug...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133012/ https://www.ncbi.nlm.nih.gov/pubmed/21760982 http://dx.doi.org/10.4061/2011/263870 |
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author | Balachandran, Kartik Sucosky, Philippe Yoganathan, Ajit P. |
author_facet | Balachandran, Kartik Sucosky, Philippe Yoganathan, Ajit P. |
author_sort | Balachandran, Kartik |
collection | PubMed |
description | Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve. Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology. Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification. |
format | Online Article Text |
id | pubmed-3133012 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31330122011-07-14 Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification Balachandran, Kartik Sucosky, Philippe Yoganathan, Ajit P. Int J Inflam Review Article Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve. Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology. Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification. SAGE-Hindawi Access to Research 2011-07-06 /pmc/articles/PMC3133012/ /pubmed/21760982 http://dx.doi.org/10.4061/2011/263870 Text en Copyright © 2011 Kartik Balachandran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Balachandran, Kartik Sucosky, Philippe Yoganathan, Ajit P. Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title | Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title_full | Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title_fullStr | Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title_full_unstemmed | Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title_short | Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification |
title_sort | hemodynamics and mechanobiology of aortic valve inflammation and calcification |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133012/ https://www.ncbi.nlm.nih.gov/pubmed/21760982 http://dx.doi.org/10.4061/2011/263870 |
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