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Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification

Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thoug...

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Autores principales: Balachandran, Kartik, Sucosky, Philippe, Yoganathan, Ajit P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133012/
https://www.ncbi.nlm.nih.gov/pubmed/21760982
http://dx.doi.org/10.4061/2011/263870
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author Balachandran, Kartik
Sucosky, Philippe
Yoganathan, Ajit P.
author_facet Balachandran, Kartik
Sucosky, Philippe
Yoganathan, Ajit P.
author_sort Balachandran, Kartik
collection PubMed
description Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve. Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology. Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification.
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spelling pubmed-31330122011-07-14 Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification Balachandran, Kartik Sucosky, Philippe Yoganathan, Ajit P. Int J Inflam Review Article Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve. Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology. Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification. SAGE-Hindawi Access to Research 2011-07-06 /pmc/articles/PMC3133012/ /pubmed/21760982 http://dx.doi.org/10.4061/2011/263870 Text en Copyright © 2011 Kartik Balachandran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Balachandran, Kartik
Sucosky, Philippe
Yoganathan, Ajit P.
Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title_full Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title_fullStr Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title_full_unstemmed Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title_short Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
title_sort hemodynamics and mechanobiology of aortic valve inflammation and calcification
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133012/
https://www.ncbi.nlm.nih.gov/pubmed/21760982
http://dx.doi.org/10.4061/2011/263870
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