Cargando…

Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration

Human neurodegenerative diseases arise from a wide array of genetic and environmental factors. Despite the diversity in etiology, many of these diseases are considered "conformational" in nature, characterized by the accumulation of pathological, misfolded proteins. These misfolded protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ali, Yousuf O., Kitay, Brandon M., Zhai, R. Grace
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133442/ https://www.ncbi.nlm.nih.gov/pubmed/20938400 http://dx.doi.org/10.3390/molecules15106859

Ejemplares similares

Autophagy and misfolded proteins in neurodegeneration
por: Metcalf, Daniel J., et al.
Publicado: (2012)

How soluble misfolded proteins bypass chaperones at the molecular level
por: Halder, Ritaban, et al.
Publicado: (2023)

Chaperoning Proteins for Destruction: Diverse Roles of Hsp70 Chaperones and their Co-Chaperones in Targeting Misfolded Proteins to the Proteasome
por: Shiber, Ayala, et al.
Publicado: (2014)

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
por: Mannini, Benedetta, et al.
Publicado: (2017)

Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins
por: Mattoo, Rayees U. H., et al.
Publicado: (2014)

Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly
por: Hervás, Rubén, et al.
Publicado: (2020)

The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration
por: Halloran, M., et al.
Publicado: (2013)

Editorial: Protein misfolding, altered mechanisms and neurodegeneration
por: Gogia, Neha, et al.
Publicado: (2023)

Protein Quality Control by Molecular Chaperones in Neurodegeneration
por: Ciechanover, Aaron, et al.
Publicado: (2017)

Editorial: Molecular Chaperones and Neurodegeneration
por: Roodveldt, Cintia, et al.
Publicado: (2017)

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
por: Underhaug, Jarl, et al.
Publicado: (2012)

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration
por: Abramov, Andrey Y., et al.
Publicado: (2020)

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes
por: Zhang, Xingqian, et al.
Publicado: (2011)

Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones
por: Rousseau, Erwann, et al.
Publicado: (2009)

Emerging novel concept of chaperone therapies for protein misfolding diseases
por: SUZUKI, Yoshiyuki
Publicado: (2014)

Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
por: Abildgaard, Amanda B., et al.
Publicado: (2020)

Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration
por: González-Sanmiguel, Juliana, et al.
Publicado: (2020)

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity
por: Brehme, Marc, et al.
Publicado: (2016)

Chaperone-mediated autophagy: roles in neurodegeneration
por: Wang, Gang, et al.
Publicado: (2014)

Secreted Chaperones in Neurodegeneration
por: Chaplot, Kriti, et al.
Publicado: (2020)

Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging
por: Cuanalo-Contreras, Karina, et al.
Publicado: (2013)

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins
por: Booth, Laurence, et al.
Publicado: (2016)

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
por: Mateju, Daniel, et al.
Publicado: (2017)

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
por: Rutledge, Benjamin S., et al.
Publicado: (2022)

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration
por: Alibhai, James, et al.
Publicado: (2016)

Osmolytes: A Possible Therapeutic Molecule for Ameliorating the Neurodegeneration Caused by Protein Misfolding and Aggregation
por: Kushwah, Neetu, et al.
Publicado: (2020)

Neuroprotection Targeting Protein Misfolding on Chronic Cerebral Hypoperfusion in the Context of Metabolic Syndrome
por: Herrera, María I., et al.
Publicado: (2018)

Chitosan-myristate nanogel as an artificial chaperone protects neuroserpin from misfolding
por: Nazem, Habib, et al.
Publicado: (2016)

Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention
por: Carman, Aaron, et al.
Publicado: (2013)

Diminished Self-Chaperoning Activity of the ΔF508 Mutant of CFTR Results in Protein Misfolding
por: Serohijos, Adrian W. R., et al.
Publicado: (2008)

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness to stress
por: Escusa-Toret, Stéphanie, et al.
Publicado: (2013)

The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
por: Jung, Jinsei, et al.
Publicado: (2016)

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins
por: Grousl, Tomas, et al.
Publicado: (2018)

Assaying Locomotor, Learning, and Memory Deficits in Drosophila Models of Neurodegeneration
por: Ali, Yousuf O., et al.
Publicado: (2011)

Dealing with difficult clients via personalized chaperone inhibitors
por: Truman, Andrew W.
Publicado: (2021)

New Insights into the Roles of Metalloproteinases in Neurodegeneration and Neuroprotection
por: Turner, A.J., et al.
Publicado: (2007)

Neurodegeneration and Neuroprotection in Glaucoma
por: Gauthier, Angela C., et al.
Publicado: (2016)

Role of Chaperone Mediated Autophagy (CMA) in the Degradation of Misfolded N-CoR Protein in Non-Small Cell Lung Cancer (NSCLC) Cells
por: Ali, Azhar Bin, et al.
Publicado: (2011)

Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches
por: Duran-Aniotz, Claudia, et al.
Publicado: (2022)

Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding
por: Semrad, Katharina
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_h0154i46tq4ctkdue859a5aiat