Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics

OBJECTIVES: The aim of this study was to comprehensively evaluate the antibacterial activity and MurE inhibition of a set of N-methyl-2-alkenyl-4-quinolones found to inhibit the growth of fast-growing mycobacteria. METHODS: Using the spot culture growth inhibition assay, MICs were determined for Myc...

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Detalles Bibliográficos
Autores principales: Guzman, Juan David, Wube, Abraham, Evangelopoulos, Dimitrios, Gupta, Antima, Hüfner, Antje, Basavannacharya, Chandrakala, Rahman, Md. Mukhleshur, Thomaschitz, Christina, Bauer, Rudolf, McHugh, Timothy Daniel, Nobeli, Irene, Prieto, Jose M., Gibbons, Simon, Bucar, Franz, Bhakta, Sanjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133487/
https://www.ncbi.nlm.nih.gov/pubmed/21622974
http://dx.doi.org/10.1093/jac/dkr203

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