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Retinoid plus antimicrobial combination treatments for acne
BACKGROUND: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. PURPOSE: To explore the e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133504/ https://www.ncbi.nlm.nih.gov/pubmed/21760743 http://dx.doi.org/10.2147/CCID.S13873 |
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author | Feneran, Ashley N Kaufman, William S Dabade, Tushar S Feldman, Steven R |
author_facet | Feneran, Ashley N Kaufman, William S Dabade, Tushar S Feldman, Steven R |
author_sort | Feneran, Ashley N |
collection | PubMed |
description | BACKGROUND: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. PURPOSE: To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris. METHODS: A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide. RESULTS: Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect. CONCLUSIONS: Combination medications have superior efficacy and adherence, and have a similar tolerability profile compared with monotherapy of its components. Several studies have found antibiotic-containing combination products with a retinoid effective for acne. The use of antibiotic-containing combination medications for acne can lead to bacterial resistance. Due to this potential for bacterial resistance, benzoyl peroxide treatments are also recommended in combination with a retinoid. |
format | Online Article Text |
id | pubmed-3133504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-31335042011-07-14 Retinoid plus antimicrobial combination treatments for acne Feneran, Ashley N Kaufman, William S Dabade, Tushar S Feldman, Steven R Clin Cosmet Investig Dermatol Review BACKGROUND: Acne vulgaris is a chronic disease with several pathogenic factors. Multiple medications are typically used that can lead to nonadherence and treatment failure. Combination medications target multiple pathways of acne formation and may offer therapeutic benefit. PURPOSE: To explore the efficacy and tolerability of combination retinoid plus antimicrobial treatments in acne vulgaris. METHODS: A PubMed and Google search was conducted for combination therapies of clindamycin and tretinoin, with secondary analysis of related citations and references. Similar searches were completed for the combination medications of benzoyl peroxide plus clindamycin or erythromycin, and for the combination therapy of adapalene and benzoyl peroxide. RESULTS: Combination clindamycin phosphate and tretinoin gel was found to be more efficacious than monotherapy of either drug or its vehicle for acne, including inflammatory acne, and has a greater onset of action than either drug alone. Clindamycin phosphate and tretinoin gel was well-tolerated, and adherence to its use exceeded that of using both medications in separate formulations. Benzoyl peroxide-containing combination medications with clindamycin or erythromycin were both more effective in the treatment of acne than either drug alone. Both medications were well-tolerated, with dry skin being the most common adverse effect. CONCLUSIONS: Combination medications have superior efficacy and adherence, and have a similar tolerability profile compared with monotherapy of its components. Several studies have found antibiotic-containing combination products with a retinoid effective for acne. The use of antibiotic-containing combination medications for acne can lead to bacterial resistance. Due to this potential for bacterial resistance, benzoyl peroxide treatments are also recommended in combination with a retinoid. Dove Medical Press 2011-07-01 /pmc/articles/PMC3133504/ /pubmed/21760743 http://dx.doi.org/10.2147/CCID.S13873 Text en © 2011 Feneran et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Feneran, Ashley N Kaufman, William S Dabade, Tushar S Feldman, Steven R Retinoid plus antimicrobial combination treatments for acne |
title | Retinoid plus antimicrobial combination treatments for acne |
title_full | Retinoid plus antimicrobial combination treatments for acne |
title_fullStr | Retinoid plus antimicrobial combination treatments for acne |
title_full_unstemmed | Retinoid plus antimicrobial combination treatments for acne |
title_short | Retinoid plus antimicrobial combination treatments for acne |
title_sort | retinoid plus antimicrobial combination treatments for acne |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133504/ https://www.ncbi.nlm.nih.gov/pubmed/21760743 http://dx.doi.org/10.2147/CCID.S13873 |
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