Cargando…

Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates sFlt-1 expression in HMVECs (human microvascular endothelial cells), a constituent of microvessels where angiogen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ikeda, Takayuki, Sun, Li, Tsuruoka, Naoki, Ishigaki, Yasuhito, Yoshitomi, Yasuo, Yoshitake, Yoshino, Yonekura, Hideto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133880/ https://www.ncbi.nlm.nih.gov/pubmed/21382012 http://dx.doi.org/10.1042/BJ20101490

Ejemplares similares

EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells
por: Ikeda, Takayuki, et al.
Publicado: (2021)

Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA
por: Ikeda, Takayuki, et al.
Publicado: (2020)

Secretion of Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1/sFlt1) Requires Arf1, Arf6, and Rab11 GTPases
por: Jung, Jae-Joon, et al.
Publicado: (2012)

Regulation of soluble vascular endothelial growth factor receptor (sFlt-1/sVEGFR-1) expression and release in endothelial cells by human follicular fluid and granulosa cells
por: Gruemmer, Ruth, et al.
Publicado: (2005)

Correction: Secretion of Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1/sFlt1) Requires Arf1, Arf6, and Rab11 GTPases
por: Jung, Jae-Joon, et al.
Publicado: (2012)

Attenuation of VEGFR-2 Expression by sFlt-1 and Low Oxygen in Human Placenta
por: Nevo, Ori, et al.
Publicado: (2013)

Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial–mesenchymal transition
por: Yoshitomi, Yasuo, et al.
Publicado: (2019)

Unraveling the Angiogenic Puzzle: Pre-Treatment sVEGFR1 and sVEGFR2 Levels as Promising Prognostic Indicators in Early-Stage Breast Cancer Patients
por: Zarychta, Elżbieta, et al.
Publicado: (2023)

Mechanical Forces Induce Changes in VEGF and VEGFR-1/sFlt-1 Expression in Human Chondrocytes
por: Beckmann, Rainer, et al.
Publicado: (2014)

PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST
por: Hansson, E K, et al.
Publicado: (2013)

Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells
por: Osada, Hiromi, et al.
Publicado: (2011)

Gene polymorphisms and serum levels of sVEGFR-1 in patients with systemic lupus erythematosus
por: Yuan, Zhi-Chao, et al.
Publicado: (2020)

Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models
por: Saito-Takatsuji, Hidehito, et al.
Publicado: (2023)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

Predicting Preeclampsia Pregnancy Termination Time Using sFlt-1
por: Tanaka, Hiroaki, et al.
Publicado: (2022)

A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells
por: Kinghorn, Karina, et al.
Publicado: (2023)

Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development
por: Yoshitomi, Yasuo, et al.
Publicado: (2021)

sVEGFR1 Is Enriched in Hepatic Vein Blood—Evidence for a Provisional Hepatic Factor Candidate?
por: Spearman, Andrew D., et al.
Publicado: (2021)

sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
por: Sapantzoglou, Ioakeim, et al.
Publicado: (2023)

RNAi Modulation of Placental sFLT1 for the Treatment of Preeclampsia.
por: Turanov, Anton A., et al.
Publicado: (2018)

sFlt-1 in Chronic Kidney Disease: Friend or Foe?
por: Matsui, Masaru, et al.
Publicado: (2022)

Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression
por: Saito-Takatsuji, Hidehito, et al.
Publicado: (2021)

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
por: Wu, Florence T H, et al.
Publicado: (2010)

Commentary: sVEGFR1 Is Enriched in Hepatic Vein Blood—Evidence for a Provisional Hepatic Factor Candidate?
por: Putotto, Carolina, et al.
Publicado: (2021)

Predictive and diagnostic value of serum sVEGFR-1 level in women with preeclampsia: A prospective controlled study
por: Şalk, Sultan, et al.
Publicado: (2022)

Doxycycline Reduces Plasma VEGF-C/sVEGFR-3 and Improves Pathology in Lymphatic Filariasis
por: Debrah, Alexander Yaw, et al.
Publicado: (2006)

VEGF and sFLT-1 in serum of PIH patients and effects on the foetus
por: Tang, Yanhong, et al.
Publicado: (2019)

Efficiency of sFlt-1/PlGF Ratio in Preeclampsia Diagnosis
por: Tataru-Copos, Anca-Florina, et al.
Publicado: (2022)

Reduced expression in preterm birth of sFLT-1 and PlGF with a high sFLT-1/PlGF ratio in extracellular vesicles suggests a potential biomarker
por: Hussein, Sama, et al.
Publicado: (2022)

Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice
por: Ku, Ching-Hsin, et al.
Publicado: (2008)

Unfractionated heparin displaces sFlt-1 from the placental extracellular matrix
por: Moore, Kyle H., et al.
Publicado: (2020)

Trophoblast-Targeted Nanomedicine Modulates Placental sFLT1 for Preeclampsia Treatment
por: Li, Lei, et al.
Publicado: (2020)

A simple detection method for the serum sFLT1 protein in preeclampsia
por: Shibuya, Masabumi, et al.
Publicado: (2021)

Clinical value of serum VEGF and sFlt-1 in pernicious placenta previa
por: Wang, Na, et al.
Publicado: (2021)

MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia
por: Yong, Qing, et al.
Publicado: (2023)

Elevation of maternal serum sFlt-1 in pregnancy with mirror syndrome caused by fetal cardiac failure
por: Katoh, Yoshihisa, et al.
Publicado: (2018)

Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells
por: Sasagawa, Tadashi, et al.
Publicado: (2020)

Difference of concentration of placental soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in severe preeclampsia and normal pregnancy
por: Gurnadi, Jeffry Iman, et al.
Publicado: (2015)

Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia
por: Souders, Colby A., et al.
Publicado: (2015)

In Vivo Experiments Reveal the Good, the Bad and the Ugly Faces of sFlt-1 in Pregnancy
por: Szalai, Gabor, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pa4ac5h3ehk9ok8695q3ahngh0