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Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing

sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report that hypoxia down-regulates sFlt-1 expression in HMVECs (human microvascular endothelial cells), a constituent of microvessels where angiogen...

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Detalles Bibliográficos
Autores principales:	Ikeda, Takayuki, Sun, Li, Tsuruoka, Naoki, Ishigaki, Yasuhito, Yoshitomi, Yasuo, Yoshitake, Yoshino, Yonekura, Hideto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133880/ https://www.ncbi.nlm.nih.gov/pubmed/21382012 http://dx.doi.org/10.1042/BJ20101490

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