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Thrombospondin-1: Multiple Paths to Inflammation
Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134184/ https://www.ncbi.nlm.nih.gov/pubmed/21765615 http://dx.doi.org/10.1155/2011/296069 |
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author | Lopez-Dee, Zenaida Pidcock, Kenneth Gutierrez, Linda S. |
author_facet | Lopez-Dee, Zenaida Pidcock, Kenneth Gutierrez, Linda S. |
author_sort | Lopez-Dee, Zenaida |
collection | PubMed |
description | Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. However, the molecular mechanisms explaining its role in inflammatory processes are not well understood. This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process. Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution. |
format | Online Article Text |
id | pubmed-3134184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31341842011-07-15 Thrombospondin-1: Multiple Paths to Inflammation Lopez-Dee, Zenaida Pidcock, Kenneth Gutierrez, Linda S. Mediators Inflamm Review Article Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. However, the molecular mechanisms explaining its role in inflammatory processes are not well understood. This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process. Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution. Hindawi Publishing Corporation 2011 2011-07-03 /pmc/articles/PMC3134184/ /pubmed/21765615 http://dx.doi.org/10.1155/2011/296069 Text en Copyright © 2011 Zenaida Lopez-Dee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lopez-Dee, Zenaida Pidcock, Kenneth Gutierrez, Linda S. Thrombospondin-1: Multiple Paths to Inflammation |
title | Thrombospondin-1: Multiple Paths to Inflammation |
title_full | Thrombospondin-1: Multiple Paths to Inflammation |
title_fullStr | Thrombospondin-1: Multiple Paths to Inflammation |
title_full_unstemmed | Thrombospondin-1: Multiple Paths to Inflammation |
title_short | Thrombospondin-1: Multiple Paths to Inflammation |
title_sort | thrombospondin-1: multiple paths to inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134184/ https://www.ncbi.nlm.nih.gov/pubmed/21765615 http://dx.doi.org/10.1155/2011/296069 |
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