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Pancreas Transplantation: Does Age Increase Morbidity?

Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patien...

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Autores principales: Afaneh, Cheguevara, Rich, Barrie S., Aull, Meredith J., Hartono, Choli, Leeser, David B., Kapur, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134200/
https://www.ncbi.nlm.nih.gov/pubmed/21766007
http://dx.doi.org/10.1155/2011/596801
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author Afaneh, Cheguevara
Rich, Barrie S.
Aull, Meredith J.
Hartono, Choli
Leeser, David B.
Kapur, Sandip
author_facet Afaneh, Cheguevara
Rich, Barrie S.
Aull, Meredith J.
Hartono, Choli
Leeser, David B.
Kapur, Sandip
author_sort Afaneh, Cheguevara
collection PubMed
description Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patients at our institution from 1996–2010; 17 were ≥50 years of age. We evaluated demographics, surgical complications, acute rejection (AR) rates, nonsurgical infections, and survival outcomes. Results. Demographic data was similar (P > .05) between groups, excluding age. The two groups had comparable major and minor surgical complication rates (P = .10 and P = .25, resp.). The older group had a lower 1-year and overall AR rate (P = .04 and P = .03, resp.). The incidence of non-surgical infections and overall patient and graft survival was similar between groups (P > .05). Conclusion. Older patients with type 1 diabetes are feasible candidates for PTx, as surgical morbidity, incidence of infections, and AR rates are low.
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spelling pubmed-31342002011-07-15 Pancreas Transplantation: Does Age Increase Morbidity? Afaneh, Cheguevara Rich, Barrie S. Aull, Meredith J. Hartono, Choli Leeser, David B. Kapur, Sandip J Transplant Clinical Study Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patients at our institution from 1996–2010; 17 were ≥50 years of age. We evaluated demographics, surgical complications, acute rejection (AR) rates, nonsurgical infections, and survival outcomes. Results. Demographic data was similar (P > .05) between groups, excluding age. The two groups had comparable major and minor surgical complication rates (P = .10 and P = .25, resp.). The older group had a lower 1-year and overall AR rate (P = .04 and P = .03, resp.). The incidence of non-surgical infections and overall patient and graft survival was similar between groups (P > .05). Conclusion. Older patients with type 1 diabetes are feasible candidates for PTx, as surgical morbidity, incidence of infections, and AR rates are low. Hindawi Publishing Corporation 2011 2011-06-04 /pmc/articles/PMC3134200/ /pubmed/21766007 http://dx.doi.org/10.1155/2011/596801 Text en Copyright © 2011 Cheguevara Afaneh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Afaneh, Cheguevara
Rich, Barrie S.
Aull, Meredith J.
Hartono, Choli
Leeser, David B.
Kapur, Sandip
Pancreas Transplantation: Does Age Increase Morbidity?
title Pancreas Transplantation: Does Age Increase Morbidity?
title_full Pancreas Transplantation: Does Age Increase Morbidity?
title_fullStr Pancreas Transplantation: Does Age Increase Morbidity?
title_full_unstemmed Pancreas Transplantation: Does Age Increase Morbidity?
title_short Pancreas Transplantation: Does Age Increase Morbidity?
title_sort pancreas transplantation: does age increase morbidity?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134200/
https://www.ncbi.nlm.nih.gov/pubmed/21766007
http://dx.doi.org/10.1155/2011/596801
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