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Flavocoxid Inhibits Phospholipase A2, Peroxidase Moieties of the Cyclooxygenases (COX), and 5-Lipoxygenase, Modifies COX-2 Gene Expression, and Acts as an Antioxidant

The multiple mechanisms of action for flavocoxid relating to arachidonic acid (AA) formation and metabolism were studied in vitro. Flavocoxid titrated into rat peritoneal macrophage cultures inhibited cellular phospholipase A2 (PLA(2)) (IC(50) = 60 μg/mL). In in vitro enzyme assays, flavocoxid showe...

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Detalles Bibliográficos
Autores principales:	Burnett, Bruce P., Bitto, Alessandra, Altavilla, Domenica, Squadrito, Francesco, Levy, Robert M., Pillai, Lakshmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134205/ https://www.ncbi.nlm.nih.gov/pubmed/21765617 http://dx.doi.org/10.1155/2011/385780

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