Recent Advances in p53 Research and Cancer Treatment

TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to...

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Detalles Bibliográficos
Autores principales: Suzuki, Kazufumi, Matsubara, Hisahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134396/
https://www.ncbi.nlm.nih.gov/pubmed/21765642
http://dx.doi.org/10.1155/2011/978312
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author Suzuki, Kazufumi
Matsubara, Hisahiro
author_facet Suzuki, Kazufumi
Matsubara, Hisahiro
author_sort Suzuki, Kazufumi
collection PubMed
description TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53-based therapy for human cancer.
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spelling pubmed-31343962011-07-15 Recent Advances in p53 Research and Cancer Treatment Suzuki, Kazufumi Matsubara, Hisahiro J Biomed Biotechnol Review Article TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We herein review the recent advances in p53 research and focus on apoptosis, cell cycle arrest, and senescence in response to stress. We also review the clinical applications of p53-based therapy for human cancer. Hindawi Publishing Corporation 2011 2011-06-16 /pmc/articles/PMC3134396/ /pubmed/21765642 http://dx.doi.org/10.1155/2011/978312 Text en Copyright © 2011 K. Suzuki and H. Matsubara. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Suzuki, Kazufumi
Matsubara, Hisahiro
Recent Advances in p53 Research and Cancer Treatment
title Recent Advances in p53 Research and Cancer Treatment
title_full Recent Advances in p53 Research and Cancer Treatment
title_fullStr Recent Advances in p53 Research and Cancer Treatment
title_full_unstemmed Recent Advances in p53 Research and Cancer Treatment
title_short Recent Advances in p53 Research and Cancer Treatment
title_sort recent advances in p53 research and cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134396/
https://www.ncbi.nlm.nih.gov/pubmed/21765642
http://dx.doi.org/10.1155/2011/978312
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