GRIM-19 Disrupts E6/E6AP Complex to Rescue p53 and Induce Apoptosis in Cervical Cancers

BACKGROUND: Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable comple...

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Detalles Bibliográficos
Autores principales: Zhou, Ying, Wei, Ying, Zhu, Jing, Wang, Qingyuan, Bao, Liang, Ma, Yang, Chen, Yu, Feng, Dingqing, Zhang, Aijin, Sun, Jie, Nallar, Shreeram C., Shen, Keng, Kalvakolanu, Dhananjaya V., Xiao, Weihua, Ling, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134474/
https://www.ncbi.nlm.nih.gov/pubmed/21765936
http://dx.doi.org/10.1371/journal.pone.0022065

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